Joanna D. Stewart

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As already previously reported the EXCLI Journal closely cooperates with the Archives of Toxicology as a partner for articles focussing on basic and clinical research (Bolt, 2011; Bolt and Stewart, 2011). To give our readers an overview over current cutting-edge topics in toxicology we publish a compilation of brief 'key messages' from the most cited(More)
We report the use of thin film poly(dimethylsiloxane) (PDMS) prints for the arrayed mass production of highly uniform 3-D human HT29 colon carcinoma spheroids. The spheroids have an organotypic density and, as determined by 3-axis imaging, were genuinely spherical. Critically, the array density impacts growth kinetics and can be tuned to produce spheroids(More)
Recently, EDI3 was identified as a key factor for choline metabolism that controls tumor cell migration and is associated with metastasis in endometrial carcinomas. EDI3 cleaves glycerophosphocholine (GPC) to form choline and glycerol-3-phosphate (G3P). Choline is then further metabolized to phosphatidylcholine (PtdC), the major lipid in membranes and a key(More)
Endometrial carcinoma differential 3 (EDI3) was the first member of the glycerophosphodiesterase (GDE) protein family shown to be associated with cancer. Our initial work demonstrated that endometrial and ovarian cancer patients with primary tumors overexpressing EDI3 had a higher risk of developing metastasis and decreased survival. Further analysis(More)
Despite the millions of Euros invested in the fight against cancer, and the progress made in cancer therapy, a major obstacle to winning the war against cancer is the ability of cancer cells to metastasize. The process of metastasis has been extensively studied, and many of the key proteins and pathways that facilitate the escape of rogue cells from the(More)
BACKGROUND Biomarkers of the immune system are currently not used as prognostic factors in breast cancer. We analyzed the association of the B cell/plasma cell marker immunoglobulin kappa C (IGKC) and survival of untreated node-negative breast cancer patients. MATERIAL AND METHODS IGKC expression was evaluated by immunostaining in a cohort of 335(More)
in Brazil accepted our invitation of a state of the art review on cisplatin-induced nephrotoxicity and strategies of nephroprotection (Santos et al. 2012; this issue). Cisplatin was accidentally discovered by Barnett Rosenberg who initially intended to kill bacteria by an electric field. Later, Rosenberg recognized that cells were not killed by the electric(More)
Due to the extremely high strength of the carbon-fluoride bond, perfluoroalkylated compounds tend to bioaccumulate in organisms. The knowledge concerning toxicity of PFCs, however, is limited. The nervous system appears to be particularly susceptible, especially when exposure occurs during development. In this issue of the Archives of Toxicology , Espen(More)
More than 300 associations between genetic polymor-phisms and approximately 70 common diseases have been identified in genome-wide association studies (review: Hindorff et al. 2009, http://www.genome.gov/gwastudies). The design of most studies included a discovery group where candidate variants were identified, which were then validated using several sets(More)
The relevance of antioxidative food constituents and the risk of developing several chronic human diseases have long been discussed. For example, the consumption of fruits and vegetables has been associated with a reduced risk of coronary atherosclerosis. This may be caused by the antioxidative activity of phenolics and flavonoids that inhibit the oxidation(More)