Joanna D. Stewart

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Recently, EDI3 was identified as a key factor for choline metabolism that controls tumor cell migration and is associated with metastasis in endometrial carcinomas. EDI3 cleaves glycerophosphocholine (GPC) to form choline and glycerol-3-phosphate (G3P). Choline is then further metabolized to phosphatidylcholine (PtdC), the major lipid in membranes and a key(More)
Endometrial carcinoma differential 3 (EDI3) was the first member of the glycerophosphodiesterase (GDE) protein family shown to be associated with cancer. Our initial work demonstrated that endometrial and ovarian cancer patients with primary tumors overexpressing EDI3 had a higher risk of developing metastasis and decreased survival. Further analysis(More)
Despite the millions of Euros invested in the fight against cancer, and the progress made in cancer therapy, a major obstacle to winning the war against cancer is the ability of cancer cells to metastasize. The process of metastasis has been extensively studied, and many of the key proteins and pathways that facilitate the escape of rogue cells from the(More)
BACKGROUND Biomarkers of the immune system are currently not used as prognostic factors in breast cancer. We analyzed the association of the B cell/plasma cell marker immunoglobulin kappa C (IGKC) and survival of untreated node-negative breast cancer patients. MATERIAL AND METHODS IGKC expression was evaluated by immunostaining in a cohort of 335(More)
Due to the extremely high strength of the carbon-fluoride bond, perfluoroalkylated compounds tend to bioaccumulate in organisms. The knowledge concerning toxicity of PFCs, however, is limited. The nervous system appears to be particularly susceptible, especially when exposure occurs during development. In this issue of the Archives of Toxicology , Espen(More)
The relevance of antioxidative food constituents and the risk of developing several chronic human diseases have long been discussed. For example, the consumption of fruits and vegetables has been associated with a reduced risk of coronary atherosclerosis. This may be caused by the antioxidative activity of phenolics and flavonoids that inhibit the oxidation(More)
In order to address the field of tension between toxicology and basic as well as clinical sciences, the editors of the Archives of Toxicology closely cooperate with our partner journal Experimental and Clinical Sciences (EXCLI Journal). To give our readers a rapid overview of recent developments, we continue our tradition to publish the key messages of(More)