Learn More
The physicochemical principle of "die and coin" complementarity proffered by Pauling and Delbruck and exemplified in Watson and Crick DNA was used to design new antineoplastic compounds. In search of an explanation for why certain molecules and not others are present in nature, biologically active small molecules were discovered to exhibit complementarity(More)
BACKGROUND A common approach to the application of epidemiological models is to determine a single (point estimate) parameterisation using the information available in the literature. However, in many cases there is considerable uncertainty about parameter values, reflecting both the incomplete nature of current knowledge and natural variation, for example(More)
Escherichia coli 0157 can cause serious illness, even death, in humans. There is some consensus that the main reservoirs of this harmful bacterium are the rumens and intestines of cattle. Hence, a stochastic model of the bovine gut was developed to investigate the in vivo population dynamics of E. coli O157. Because bacterial numbers can reach minimal(More)
3-Phenylactetylamino-2,6-piperidinedione (A10) inhibited estradiol stimulated cell growth in the MCF-7 (E3) human breast tumor cell line in vivo and in vitro. While high concentrations of A10 were needed to inhibit cell proliferation (IC50 = 3 x 10(-3) M in vitro), the compound demonstrated little toxicity. The effect appeared specific since a hydrolysis(More)
  • 1