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Identical twins developed myoclonic epilepsy in their teens. One twin remained mildly affected but the other went on to develop sensorineural deafness and ataxia with lactic acidosis and ragged red fibres leading to a diagnosis of mitochondrial encephalopathy. Multiple stroke-like episodes with hemiparesis followed, indicating progression from a MERRF to a(More)
Four patients are described with proven subacute extradural haematomas, each with an abnormal cerebral scan of diagnostic assistance. A possible mechanism of production of the subacute extradural haematoma is discussed, and appears to be similar to the mechanism involved in the subacute subdural haematoma. The means by which the abnormal scan results in(More)
Recently attention has been directed to the various non-metastatic neurological manifestations of malignant diseases, and myeloma, noted for its presentation by signs of compression and infiltration, is less widely known in association with chronic symmetrical polyradiculoneuropathy. This paper discusses certain clinical aspects of this neuropathy. We have(More)
Neuropathological studies were carried out in two patients with mitochondrial encephalomyopathies in whom the underlying lesions in muscle mitochondrial DNA (mtDNA) and respiratory enzyme complexes have been investigated. The first, a man with Kearns-Sayre syndrome, died at the age of 49 years. Autopsy showed an old parietal lobe infarct, diffuse spongiform(More)
Despite extensive research on running mechanics, there is still a knowledge gap with respect to the degree of relationship between mediolateral ground reaction forces (ML-GRF) and foot pronation. Our goal was to investigate whether differences exist in ML-GRF among runners that exhibit different degrees of pronation. Seventeen male and 13 female(More)
This paper presents evidence of preservation of acquired music performance functions in a right-handed man with a large dominant hemisphere lesion. Results of music testing, speech pathology testing, neuropsychological testing and neurological examination are presented, with evidence of intact music skills (melodic perception and an ability to read at(More)