Joann E. Manson

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Department of Nutritional Sciences (A.C.R.), Pennsylvania State University, University Park, Pennsylvania 16802; Department of Medicine (J.E.M.), Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02215; Department of Pediatrics (S.A.A.), Baylor College of Medicine, Houston, Texas 77030; Department of Medicine (J.F.A.), State(More)
CONTEXT Inflammation is hypothesized to play a role in development of type 2 diabetes mellitus (DM); however, clinical data addressing this issue are limited. OBJECTIVE To determine whether elevated levels of the inflammatory markers interleukin 6 (IL-6) and C-reactive protein (CRP) are associated with development of type 2 DM in healthy middle-aged(More)
OBJECTIVE To examine prospectively the relationship between glycemic diets, low fiber intake, and risk of non-insulin-dependent diabetes mellitus. DESIGN Cohort study. SETTING In 1986, a total of 65173 US women 40 to 65 years of age and free from diagnosed cardiovascular disease, cancer, and diabetes completed a detailed dietary questionnaire from which(More)
BACKGROUND Little is known about the effects of the amount and type of carbohydrates on risk of coronary heart disease (CHD). OBJECTIVE The objective of this study was to prospectively evaluate the relations of the amount and type of carbohydrates with risk of CHD. DESIGN A cohort of 75521 women aged 38-63 y with no previous diagnosis of diabetes(More)
CONTEXT Current public health campaigns to reduce obesity and type 2 diabetes have largely focused on increasing exercise, but have paid little attention to the reduction of sedentary behaviors. OBJECTIVE To examine the relationship between various sedentary behaviors, especially prolonged television (TV) watching, and risk of obesity and type 2 diabetes(More)
CONTEXT Despite decades of use and considerable research, the role of estrogen alone in preventing chronic diseases in postmenopausal women remains uncertain. OBJECTIVE To assess the effects on major disease incidence rates of the most commonly used postmenopausal hormone therapy in the United States. DESIGN, SETTING, AND PARTICIPANTS A randomized,(More)
BACKGROUND Previous studies have examined individual dietary and lifestyle factors in relation to type 2 diabetes, but the combined effects of these factors are largely unknown. METHODS We followed 84,941 female nurses from 1980 to 1996; these women were free of diagnosed cardiovascular disease, diabetes, and cancer at base line. Information about their(More)
BACKGROUND The efficacy of calcium with vitamin D supplementation for preventing hip and other fractures in healthy postmenopausal women remains equivocal. METHODS We recruited 36,282 postmenopausal women, 50 to 79 years of age, who were already enrolled in a Women's Health Initiative (WHI) clinical trial. We randomly assigned participants to receive 1000(More)
OBJECTIVE To examine the relation between adult weight change and the risk for clinical diabetes mellitus among middle-aged women. DESIGN Prospective cohort study with follow-up from 1976 to 1990. SETTING 11 U.S. states. PARTICIPANTS 114,281 female registered nurses aged 30 to 55 years who did not have diagnosed diabetes mellitus, coronary heart(More)
BACKGROUND Many constituents of fruits and vegetables may reduce the risk for coronary heart disease, but data on the relationship between fruit and vegetable consumption and risk for coronary heart disease are sparse. OBJECTIVE To evaluate the association of fruit and vegetable consumption with risk for coronary heart disease. DESIGN Prospective cohort(More)