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This paper addresses methods of knowledge engineering for chemical and biochemical process modelling and control. The concept of Knowledge Based Modular (KBM) Networks is presented. KBM networks represent a method of expressing and combining different types of knowledge, usually available for modelling chemical and biochemical processes: mechanistic,(More)
In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: Abstract This paper presents a novel method for bioprocess hybrid(More)
Keywords: Hybrid modeling Dynamic modeling Nonlinear partial least square (nonlinear projection to latent structures) Artificial neural networks Bordetella pertussis a b s t r a c t This paper presents a method for the identification of nonlinear partial least square (NPLS) models embedded in macroscopic material balance equations with application to(More)
BACKGROUND This paper presents a method for modelling dynamical biochemical networks with intrinsic time delays. Since the fundamental mechanisms leading to such delays are many times unknown, non conventional modelling approaches become necessary. Herein, a hybrid semi-parametric identification methodology is proposed in which discrete time series are(More)
Keywords: Dynamic neural networks Hybrid semi-parametric modeling Numerical integration Ordinary differential equations Differential equations a b s t r a c t The Ordinary Differential Equations (ODEs) of dynamic models that are used in process monitoring, control or optimization, are not only functions of time and states, but also of measured variables. So(More)
In this paper a novel methodology for biosystems dynamic modelling is presented in which discrete time series, namely AutoRegressive (eXogenous) models are incorporated in the traditional parametric/nonparametric hybrid modelling framework. This results in a set of Delay Differential Equations (DDE) which describe the material balances of a bioreactor(More)
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