Joana B. Nunes

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Mitochondria are central organelles for cellular metabolism. In cancer cells, mitochondrial oxidative phosphorylation (OXPHOS) dysfunction has been shown to promote migration, invasion, metastization and apoptosis resistance. With the purpose of analysing the effects of OXPHOS dysfunction in cancer cells and the molecular players involved, we generated(More)
We would like to report a genetic screening of SDHB, SDHC, SDHD and SDHAF2 genes (hereafter abbreviated to SDHx) in patients with paragangliomas (PGL) and phaeochromocytomas (PCC) from northern Portugal. PGL and PCC are neuroendocrine tumours that can be caused by heterozygous germline loss-of-function mutations in SDHx genes (Gimenez-Roqueplo et al. 2012).(More)
Somatic mutations in GNAQ gene were described as being the main oncogenic activation in uveal melanomas, whereas mutations in BRAF gene have been described as a key genetic alteration that contributes to skin melanoma development. We have previously reported differential activation of the MAPK and AKT/mTOR signalling pathways in uveal and skin melanomas(More)
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