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Ophthalmologic examinations for cataract, glaucoma, diabetic retinopathy, macular degeneration and visual acuity were performed on 2631 of the 3977 members of the Framingham (Massachusetts) Heart Study population still living in 1973-1975. The subjects ranged in age from 52 to 85 years. This monograph presents the detailed protocols and record forms for(More)
BACKGROUND In myocardial infarction patients, heart rate-adjusted QT interval (QTc), an electrocardiographic indicator of sympathetic balance, is prognostic for survival. METHODS AND RESULTS In a 28-year follow-up, the association between QTc and all-cause, cardiovascular, and ischemic heart disease mortality was studied in a population of 3,091(More)
BACKGROUND Low heart rate variability has been implicated as a risk factor for sudden death. However, no large epidemiological studies using sudden death as an outcome event have been reported. METHODS AND RESULTS A total of 6,693 consecutive patients who underwent 24-hour ambulatory ECG were followed up for 2 years; of these, 245 patients died suddenly.(More)
BACKGROUND QTc prolongation has been implicated as a risk factor for sudden death; however, a controversy exists over its significance. METHODS AND RESULTS In the Rotterdam QT Project, 6,693 consecutive patients who underwent 24-hour ambulatory electrocardiography were followed up for 2 years; of these, 245 patients died suddenly. A standard 12-lead(More)
Low heart rate variability is associated with high risk of sudden death in myocardial infarction patients. This has been attributed to unfavorable autonomic cardiac control. In the present study, the predictive value of heart rate variability for sudden death, mortality from coronary heart disease, and from all causes was investigated in the general(More)
OBJECTIVE To study the effects of variability in the duration of the QT interval corrected for heart rate (QTc) on the occurrence of sudden death. DESIGN Nested case-referent study. SUBJECTS Cohort of 6693 consecutive patients who underwent 24 hour electrocardiography and were followed up for two years. Risk implications of QTc interval variables were(More)
The Framingham Study has investigated the effect of host and environmental factors on the development of coronary heart disease since 1949. Serum cholesterol level was determined to the one of the risk factors for coronary heart disease. The nutrient intake, in a subsample of the study population, was determined in 1957. A review of this material has(More)
Some anthropological and physiological measurements were taken in 38 competitors of the European championship for female gymnasts in 1967 in Amsterdam. Female top gymnasts were characterized by small height (mean 1.58 m) and weight (mean 52.6 kg). They had extraordinarily small skinfolds, which correlated negatively with their performance. Muscles were well(More)
Maximum oxygen uptake ( $$\dot V_{{\text{o}}_{\text{2}} }$$ max), maximum heart rate (MHR), blood lactic acid (LA) and pH were measured during bicycle ergometer exercise in 52 men, 22 to 60 years old, engaged in clerical and light manual work (prison personnel and prisoners in the Netherlands). $$\dot V_{{\text{o}}_{\text{2}} }$$ max decreases with, age,(More)