Joan Baptista

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Changes in lipid plasma levels during malaria attacks have been proposed for use in diagnosis or to assess the severity of the disease. In order to analyse the plasma levels of cholesterol, triglycerides, HDL-C et LDL-C, we compared, in an endemic area (São Tomé island), two groups of patients children infected with Plasmodium falciparum (simple malaria(More)
A high-performance liquid chromatography (HPLC) method with pulsed amperometric detection (PAD) was used for the determination of the acid hydrolysis products of L-iduronic acid containing oligosaccharides isolated from biological sources. This HPLC-PAD method was compared with gas chromatographic (GLC) methods. Since acid hydrolysis of oligosaccharides can(More)
The preparation of hydroxyapatite coatings on alumina substrates by a sol-gel method was investigated. A mixed ethanol solution of Ca(NO3)2.4H2O and P2O5 was used as a dipping source. The samples were characterized by solid-state 31P nuclear magnetic resonance spectroscopy, differential thermal analysis, thermogravimetry, X-ray diffraction, scanning(More)
Cell-mediated immunity and cytokines are probably involved in the pathogenesis of malaria. To investigate the role and the activity of different immune cells, we measured levels of tumour necrosis factor-(TNF-alpha), gamma interferon (IFN-gamma) and several interleukins (IL-2, IL-4, IL-6 and IL-10) in children with mild (MM) and cerebral (CM) Plasmodium(More)
Vertical migratory rhythms of the western Mediterranean congeneric benthopelagic glass shrimps Pasiphaea sivado and P. multidentata were studied at depths of 400 to 430 m in relation to light intensity cycles (i.e. light regimes) in 2 different seasons: close to the autumn equinox (October) and to the summer solstice (June). Catches were considered a proxy(More)
Using a historical approach of malaria control in the island of São Tomé, the author describes the evolution of strategies used with special reference to the last 25 years. From a zero mortality rate in children under 4 years in 1981/83, malaria became the first cause of morbidity and mortality after the epidemic of 1985/86. Malaria was introduced in 1493,(More)
Plasmodium falciparum sensitivity to quinine in São Tomé was determined by in vivo and in vitro tests in 56 children with mild or cerebral malaria. Chloroquine sensitivity was assessed by in vitro tests in 105 parasitaemic asymptomatic children from the same community as the cases. The WHO standard methodology was used. No resistance to quinine was found by(More)
Since the first description of stress syndrome, by Hans Selye in 1936, much has been investigated concerning the etiological mechanisms of stress. In recent years the intense research in the field of the neurobiology of stress, namely in Post-Traumatic Stress Disorder (PTSD), revealed some of the mechanisms and neurological structures involved with stress.(More)
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