Joachim Vilstrup

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Coronary artery disease is the main cause of death worldwide and accelerated by increased plasma levels of cholesterol-rich low-density lipoprotein particles (LDL). Circulating PCSK9 contributes to coronary artery disease by inducing lysosomal degradation of the LDL receptor (LDLR) in the liver and thereby reducing LDL clearance. Here, we show that liver(More)
a Interfaculty Institute of Biochemistry, University Tübingen, Hoppe-Seyler-Str. 4, 72076 Tübingen, Germany. b Department of Molecular Biology and Genetics, Aarhus University, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark. c Leibniz Institute for Natural Product Research and Infection Biology (HKI), 07745 Jena, Germany. d Max Planck Institute for Plant(More)
Corallopyronin A is a polyketide derived from the myxobacterium Corallococcus coralloides with potent antibiotic features. The gene cluster responsible for the biosynthesis of corallopyronin A has been described recently, and it was proposed that CorB acts as a ketosynthase to interconnect two polyketide chains in a rare head-to-head condensation reaction.(More)
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