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- Publications
- Influence
Activation mechanisms of STAT5 by oncogenic Flt3-ITD.
- C. Choudhary, C. Brandts, +7 authors H. Serve
- Biology, Medicine
- Blood
- 16 November 2006
Mutations in the receptor tyrosine kinase Flt3 represent a very common genetic lesion in acute myeloid leukemia (AML). Internal tandem duplication (ITD) mutations clustered in the juxtamembrane… Expand
Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations.
- M. Mizuki, Joachim Schwable, +10 authors H. Serve
- Biology, Medicine
- Blood
- 15 April 2003
The receptor tyrosine kinase Flt3 is expressed and functionally important in early myeloid progenitor cells and in the majority of acute myeloid leukemia (AML) blasts. Internal tandem duplications… Expand