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OBJECTIVE To assess the long-term efficacy and safety of infliximab plus methotrexate in juvenile rheumatoid arthritis (JRA). METHODS Patients eligible for the open-label extension (OLE, weeks 52-204) received infliximab 3-6 mg/kg every 8 weeks plus methotrexate. RESULTS Of the 78/122 (64%) children entering the OLE, 42 discontinued infliximab, most(More)
BACKGROUND Rheumatoid arthritis (RA) and juvenile rheumatoid arthritis (JRA) are complex multifactorial diseases caused by environmental influences and an unknown number of predisposing genes. The present study was undertaken in order to investigate association of polymorphisms in candidate genes with RA and JRA in German subjects. RESULTS Up to 200(More)
OBJECTIVE To evaluate the safety and efficacy of autologous stem cell transplantation (ASCT) for refractory juvenile idiopathic arthritis (JIA). DESIGN Retrospective analysis of follow up data on 34 children with JIA who were treated with ASCT in nine different European transplant centres. Rheumatological evaluation employed a modified set of core(More)
BACKGROUND We investigated the prognostic role of tumour-associated macrophages (TAMs) in patients with head and neck squamous cell carcinoma (HNSCC) treated with definitive chemoradiotherapy (CRT). METHODS The expression of CD68+, CD163+ and CD11b+ cells was assessed using immunohistochemistry in n=106 pre-treatment tumour biopsy samples and was(More)
OBJECTIVE These studies evaluated the feasibility of using oral prolonged-release oxycodone/naloxone (OXN PR) for the management of acute postoperative pain. METHODS Three studies were undertaken: (i) the analgesic efficacy of OXN PR was compared with prolonged-release oxycodone (OXY PR) in patients with knee arthroplasty in an immediate postoperative(More)
Twenty patients with polyarticular or systemic subtypes of juvenile chronic arthritis were primary treated with either Methylprednisolone (MP) pulses (group I) or i.v. Immunoglobulin (IG) (group II) in combination with Methotrexat and low dosages of Glucocorticosteroids. Clinical effects of treatment were rapid and excellent in both groups and also the(More)
In normal children about under PHA 67% of the lymphocytes, but only 8% under AHLG show a blast transformation. Children with juvenile rheumatoid arthritis reveal (in autologeous serum) a PHA-reactivity of the normal range, whereas the transformation rate under AHLG is increased on more than 60%. In immune proliferative disease the results are different.(More)