Joachim Knop

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BACKGROUND In 1979 through 1980, electroencephalographic (EEG) responses to an alcohol challenge in 19 year-old sons of alcoholics as well as in sons of nonalcoholic control subjects were examined. The familial risk status of the subjects and greater EEG sensitivity to alcohol were hypothesized to predict the development of alcoholism 10 years later. (More)
OBJECTIVE This study examines the role of elevated autonomic nervous system reactivity in protecting individuals at high risk for criminal behavior from antisocial outcomes. The authors hypothesized that subjects with criminal fathers who did not become criminals themselves were biologically protected from such an outcome because of, in part, heightened(More)
The biologic sons of alcoholics constitute a group at high risk (HR) for alcoholism. A 0.5-g/kg dose of alcohol was administered to HR and control subjects aged 19 to 21 years. Blood alcohol concentration measurements failed to distinguish HR from control subjects, but quantitative measurements of EEG alpha activity differentiated them. The HR subjects(More)
  • Joachim Knop
  • Recent developments in alcoholism : an official…
  • 1985
The high-risk paradigm has been applied to a group of sons of alcoholic fathers and a control group without parental alcoholism. The sample is selected from a Danish birth cohort (1959 to 1961) including 8949 consecutive deliveries. A multidisciplinary assessment was undertaken when the subjects were 18 to 19 years old. The over-all results from this(More)
BACKGROUND Understanding the comorbidity of alcohol use disorders (AUD) and other psychiatric disorders may have important implications for treatment and preventive interventions. However, information on the epidemiology of this comorbidity is lacking. The objective of this study was to present results on lifetime psychiatric comorbidity of AUD in a large(More)
Hierarchical logistic regression was used to assess the independent and interactive effects of paternal alcoholism and physical child abuse on antisocial behavior in young adult men. Men with alcoholic fathers (N = 131) did not report or exhibit more antisocial behavior than comparison subjects (N = 70). Men with physical abuse histories, however, reported(More)
OBJECTIVE In a search for viable endophenotypes of alcoholism, this longitudinal study attempted to identify premorbid predictors of alcohol dependence that also predicted the course of alcoholism. METHOD The 202 male subjects who completed a 40-year follow-up were originally selected from a Danish birth cohort (N = 9,182). Two thirds of the subjects were(More)
INTRODUCTION Compared with controls, up to six years after their return, Danish Gulf War veterans have a significantly higher prevalence of self-reported neuropsychological symptoms, potentially as a result of neurotoxic exposure during deployment. We tested the hypotheses that: 1) GW veterans would perform less well than controls using a computerized(More)
OBJECTIVE The Danish Longitudinal Study on Alcoholism was designed to identify antecedent predictors of adult male alcoholism. The influence of premorbid behaviors consistent with childhood conduct disorder (CD) and attention-deficit/hyperactivity disorder (ADHD) on the development of alcohol misuse was examined. METHOD Subjects were selected from a(More)
Biological sons of alcoholic men constitute one group at high risk (HR) for the development of alcoholism. A low dose of alcohol (0.5 g/kg) was administered to HR and control subjects. Measures based on self-ratings, an observer's assessment and visuomotor performance were used to compare the HR and control subjects before and after alcohol administration.(More)