JoEllyn C Moore

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OBJECTIVE The authors' goal was to determine if there is an association between brain-to-serum lithium ratios and age. METHOD Lithium-7 magnetic resonance spectroscopy was used to measure in vivo brain lithium levels in nine children and adolescents (mean age=13.4 years, SD=3.6) and 18 adults (mean age=37.3, SD=9.1) with bipolar disorder. RESULTS Serum(More)
BACKGROUND The frontal lobe has been implicated in the pathology of depression in adults. Through the use of magnetic resonance spectroscopy, altered brain choline levels have also been linked to the pathophysiology of affective disorders. METHODS To identify possible alterations in orbitofrontal cortex levels of cytosolic choline in adolescents with and(More)
Recent studies investigating thrombotic thrombocytopenic purpura (TTP) have implicated abnormal plasma von Willebrand factor (vWF)-cleaving metalloprotease activity in this disorder. It has been proposed that a metalloprotease cleaves unusually large (UL) multimers of vWF, which enter the circulation from the endothelium. Abnormal metalloprotease activity(More)
Thrombotic thrombocytopenic purpura (TTP) is characterized by thrombocytopenia and disseminated platelet thrombi throughout the microvasculature. Studies by our group have demonstrated calcium-dependent proteolytic activity (calpain) that is no longer detectable in the serum of patients with acute TTP after their recovery. The purpose of this study was to(More)
An association between aortic stenosis and haemorrhage from gastrointestinal angiodysplasia has been recognised for many years, but no explanation for this link has been found. Remarkably, aortic valve replacement, rather than bowel resection, corrects the bleeding. Aortic stenosis can be complicated by acquired von Willebrand's disease type IIA (vWD-IIA),(More)
  • J C Moore
  • 1975
The amount of excitation overflow into a nonactive upper limb can be predicted when the active limb is isometrically contracted during a standardized exercise. Bilateral electromyographic recordings from the biceps brachii and brachialis demonstrated that the amount of excitation overflow in the nonactive limb is between 10 percent and 20 percent of the(More)
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