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- Publications
- Influence
Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and…
- Jo-Hua Chiang, J. Yang, +7 authors J. Chung
- Biology, Medicine
- Chemical research in toxicology
- 14 January 2011
Anthraquinones have been shown to induce apoptosis in different types of tumor cells, but the mechanisms of danthron-induced cytotoxicity and apoptosis in human gastric cancer cells have not been… Expand
Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: roles of apoptotic cell death and LS1034 tumor xenografts model.
- Yi-Shih Ma, Shu-Wen Weng, +8 authors J. Chung
- Biology, Medicine
- Food and chemical toxicology : an international…
- 1 May 2012
Emodin, an active natural anthraquinone derivative, is found in the roots and rhizomes of numerous Chinese medicinal herbs and exhibits anticancer effects on many types of human cancer cell lines.… Expand
Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade- and mitochondria-dependent pathways.
- Shin-Hwar Wu, Liang Hang, +8 authors J. Chung
- Biology, Medicine
- Anticancer research
- 1 June 2010
It has been reported that curcumin inhibited various types of cancer cells in vitro and in vivo. However, mechanisms of curcumin-inhibited cell growth and -induced apoptosis in human non-small cell… Expand
Safrole Induces Apoptosis in Human Oral Cancer HSC-3 Cells
Phytochemicals have been used as potential chemopreventive or chemotherapeutic agents. However, there are data suggesting a mutagenic effect of some phytochemicals. We hypothesized that safrole would… Expand
Gallic acid induces apoptosis via caspase-3 and mitochondrion-dependent pathways in vitro and suppresses lung xenograft tumor growth in vivo.
- Bin-Chuan Ji, Wu-Huei Hsu, +9 authors J. Chung
- Biology, Medicine
- Journal of agricultural and food chemistry
- 27 July 2009
Several studies have shown that gallic acid (GA) induces apoptosis in different cancer cell lines, whereas the mechanism of action of GA-induced apoptosis at the molecular level in human… Expand
Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways.
- Wen-Wen Huang, Shih-Wei Ko, +7 authors J. Yang
- Biology, Medicine
- International journal of oncology
- 1 April 2011
Cantharidin (CTD) is a traditional Chinese medicine and an effective component isolated from blister beetle, and it has been demonstrated to have anticancer, antibiotic, antivirus activities and… Expand
Gallic acid suppresses the migration and invasion of PC-3 human prostate cancer cells via inhibition of matrix metalloproteinase-2 and -9 signaling pathways.
Epidemiological studies have demonstrated that a natural diet or consumption of fruits or vegetables can decrease the risk of cancer development. Cancer cells can migrate to and invade other organs… Expand
Wogonin triggers apoptosis in human osteosarcoma U-2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase-3-dependent signaling pathways.
- Chin-Chung Lin, Chao-Lin Kuo, +8 authors J. Chung
- Biology, Medicine
- International journal of oncology
- 1 July 2011
Wogonin (5,7-dihydroxy-8-methoxyflavone) is a flavone constituent of Scutellaria baicalensis with various beneficial biological activities and it has been shown to have tumor therapeutic potential in… Expand
Chrysin, a natural and biologically active flavonoid, influences a murine leukemia model in vivo through enhancing populations of T-and B-cells, and promoting macrophage phagocytosis and NK cell…
- Chin-Chung Lin, Chun-Shu Yu, +5 authors J. Chung
- Biology, Medicine
- In vivo
- 1 July 2012
Chrysin (5,7-dihydroxyflavone), a natural and biologically active flavonoid found in plants, possesses many biological activities and anticancer effects. However, there is no available evidence… Expand
Newly synthesized quinazolinone HMJ-38 suppresses angiogenetic responses and triggers human umbilical vein endothelial cell apoptosis through p53-modulated Fas/death receptor signaling.
- Jo-Hua Chiang, J. Yang, +4 authors J. Chung
- Biology, Medicine
- Toxicology and applied pharmacology
- 1 June 2013
The current study aims to investigate the antiangiogenic responses and apoptotic death of human umbilical vein endothelial cells (HUVECs) by a newly synthesized compound named… Expand
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