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Our understanding of the mammalian inwardly rectifying family of K+ channels (Kir family) has recently been advanced by X-ray crystal structures of two homologous prokaryotic orthologs (KirBac1.1 and KirBac3.1). However, the functional properties of these KirBac channels are still poorly understood. To address this problem, we cloned and characterized genes(More)
The aim of this study was to identify the mutation site and phenotype of the Duchenne muscular dystrophy (DMD) gene in a DMD family. The DMD gene is by far the largest known gene in humans. Up to 34% of the point mutations reported to date affect splice sites of the DMD gene. However, no hotspot mutation has been reported. Capture sequencing of(More)
Sun, Si, Jo Han Gan, Jennifer J. Paynter, and Stephen J. Tucker. Cloning and functional characterization of a superfamily of microbial inwardly rectifying potassium channels. Physiol Genomics 26: 1–7, 2006. First published April 4, 2006; doi:10.1152/physiolgenomics.00026.2006.—Our understanding of the mammalian inwardly rectifying family of K channels (Kir(More)
Our understanding of the mammalian inwardly-rectifying (Kir) family of potassium channels has recently been advanced by X-ray crystal structures of two homologous prokaryotic orthologs (KirBac1.1 and KirBac3.1). However, the functional properties of these KirBac channels are still poorly understood. To address this problem we have cloned and characterised(More)
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