Jo Anne Shannon

Learn More
Cocaine abuse in methadone maintenance patients has emerged as a significant clinical problem. To determine if raising the daily methadone dosage is an effective way to eliminate cocaine abuse, 74 methadone maintenance patients maintained at daily dosages between 30 and 80 mg and who chronically abused cocaine were studied by a standard protocol. A total of(More)
Adrenal gland metabolism is markedly altered in heroin addicts. During daytime hours, the addict may suffer corticoid deficiency of the addisonian type, and in the evening, an excess of the cushingoid type. The high plasma levels of cortisol that are found in the evening in addicts antagonize endogenous opioids in a manner similar to naloxone. In the(More)
In a previous paper the evidence on the excretion of carbohydrates by the toadfish, goosefish, dogfish, dog and man was reviewed and it was concluded that, until evidence to the contrary is adduced, all the available facts are best interpreted on the supposition that pure carbohydrates in general are not secreted by the renal tubules of any of the(More)
The relative effectiveness of the various cinchona alkaloids in the treatment of malaria has been the subject of numerous investigations since the meeting of the Madras Commission in 1868 (1). Without exception, studies undertaken prior to the recent war involved the appraisal of the comparative antimalarial activities of quinine, quinidine, cinchonine and(More)