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Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ.

• Agustin Casimiro-Garcia, Gary F Filzen, +14 authors Chad L. Stoner
• Journal of medicinal chemistry
• 2011

Mining of an in-house collection of angiotensin II type 1 receptor antagonists to identify compounds with activity at the peroxisome proliferator-activated receptor-γ (PPARγ) revealed a new series of… (More)

Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ.

• Agustin Casimiro-Garcia, Ronald J Heemstra, +10 authors Noel A. Powell
• Bioorganic & medicinal chemistry letters
• 2013

Identification of a series of imidazo[4,5-c]pyridin-4-one derivatives that act as dual angiotensin II type 1 (AT1) receptor antagonists and peroxisome proliferator-activated receptor-γ (PPARγ)… (More)

Building a comprehensive team for the longitudinal care of single ventricle heart defects: Building blocks and initial results.

• Karen Texter, Jo Ann M Davis, +4 authors Timothy F. Feltes
• Congenital heart disease
• 2017

INTRODUCTION With increasing survival of children with HLHS and other single ventricle lesions, the complexity of medical care for these patients is substantial. Establishing and adhering to best… (More)

Motion to Adjourn Not Voting—9

• M. D. Olver, Mr Mcnulty, +226 authors Geoffrey Norman Watson

move that the House do now adjourn. The SPEAKER pro tempore. The question is on the motion to adjourn offered by the gentleman from New York (Mr. MCNULTY). The question was taken; and the Speaker pro… (More)

Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARalpha/gamma dual agonists, and X-ray crystallographic studies.

• Agustin Casimiro-Garcia, Christopher F. Bigge, +13 authors Hairong Zhou
• Bioorganic & medicinal chemistry
• 2008

A new series of alpha-aryl or alpha-heteroarylphenyl propanoic acid derivatives was synthesized that incorporate acetylene-, ethylene-, propyl-, or nitrogen-derived linkers as a replacement of the… (More)

Launching a New Strategy for Multidisciplinary Management of Single-Ventricle Heart Defects.

• Jo Ann M Davis, Holly Miller-Tate, Karen Texter
• Critical care nurse
• 2018

Children born with single-ventricle heart defects, particularly hypoplastic left heart syndrome, have a lifetime high risk of mortality and comorbidities. They have complex medical challenges in… (More)

Not Voting—14 Mr. Obey. Mr Speaker, Could We Make It 20 Minutes on This Side?

• Bentsen Carson, Hastings Filner, +221 authors Florida Mr Speaker

The question was taken; and the Speaker pro tempore announced that the noes appeared to have it. b 1110 So the motion to adjourn was rejected. The result of the vote was announced as above recorded.… (More)

Synthesis and evaluation of novel alpha-heteroaryl-phenylpropanoic acid derivatives as PPARalpha/gamma dual agonists.

• Agustin Casimiro-Garcia, Christopher F. Bigge, +11 authors Kun Song
• Bioorganic & medicinal chemistry
• 2009

The synthesis of a new series of phenylpropanoic acid derivatives incorporating an heteroaryl group at the alpha-position and their evaluation for binding and activation of PPARalpha and PPARgamma… (More)

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