João Vinagre

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Reactivation of telomerase has been implicated in human tumorigenesis, but the underlying mechanisms remain poorly understood. Here we report the presence of recurrent somatic mutations in the TERT promoter in cancers of the central nervous system (43%), bladder (59%), thyroid (follicular cell-derived, 10%) and skin (melanoma, 29%). In thyroid cancers, the(More)
CONTEXT Telomerase promoter mutations (TERT) were recently described in follicular cell-derived thyroid carcinomas (FCDTC) and seem to be more prevalent in aggressive cancers. OBJECTIVES We aimed to evaluate the frequency of TERT promoter mutations in thyroid lesions and to investigate the prognostic significance of such mutations in a large cohort of(More)
Traditional Collaborative Filtering algorithms for recommendation are designed for stationary data. Likewise, conventional evaluation methodologies are only applicable in offline experiments, where data and models are static. However, in real world systems, user feedback is continuously being generated, at unpredictable rates. One way to deal with this data(More)
Cell immortalization has been considered for a long time as a classic hallmark of cancer cells. Besides telomerase reactivation, such immortalization could be due to telomere maintenance through the “alternative mechanism of telomere lengthening” (ALT) but the mechanisms underlying both forms of reactivation remained elusive. Mutations in the coding region(More)
Physical activity (PA) in children/adolescents of both genders from a rural community in Mozambique was estimated by accelerometry and by questionnaire and was compared with PA of Portuguese youth. Total PA, moderate (MPA), vigorous (VPA) and very vigorous (VVPA) were evaluated. Mozambican boys were more active than girls. Intensity of PA declined(More)
In the thyroid, primary neuroendocrine tumors encompass medullary thyroid carcinoma (MTC) and, rarely, other tumors such as paragangliomas. MTCs are derived from C-cells and express calcitonin and neuroendocrine markers. Besides classic MTC, some reports have documented thyroid neuroendocrine tumors, which show no calcitonin expression and raise difficult(More)
Gastrointestinal stromal tumors (GISTs) are the most common mesenchyme neoplasms of the gastrointestinal tract. Gain-of-function somatic mutations of the KIT or PDGFRA genes represent the most prevalent molecular alterations in GISTs. In Carney–Stratakis dyad, patients portray germline mutations of the succinate dehydrogenase subunits B (SDHB), C (SDHC) and(More)
Collaborative filtering (CF) has been an important subject of research in the past few years. Many achievements have been made in this field, however, many challenges still need to be faced, mainly related to scalability and predictive ability. One important issue is how to deal with old and potentially obsolete data in order to avoid unnecessary memory(More)
The reactivation or reexpression of telomerase (TERT) is a widespread feature of neoplasms. TERT promoter mutations were recently reported that were hypothesized to result from UV radiation. In this retrospective study, we assessed TERT promoter mutations in 196 cutaneous basal cell carcinomas (BCCs), including 102 tumors from X-irradiated patients, 94(More)
The significance of RET in thyroid cancer comes from solid evidence that, when inherited, an RET activating mutation primes C-cells to transform into medullary carcinomas. Moreover, environmental exposure to radiation also induces rearranged transforming RET "isoforms" that are found in papillary thyroid cancer. The RET gene codes for a tyrosine kinase(More)