João Paulo Pereira

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Buruli ulcer (BU) is a devastating, necrotizing, tropical skin disease caused by infections with Mycobacterium ulcerans. In contrast to other mycobacterioses, BU has been associated with minimal or absent inflammation. However, here we show that in the mouse M. ulcerans induces persistent inflammatory responses with virulence-dependent patterns.(More)
Throughout the last decade many approaches have been made to the problem of developing CAD systems that are usable in the early stages of product ideation. Although most of these approaches rely on some kind of drawing paradigm and on the paper-and-pencil metaphor, only a few of them deal with the ambiguity that is inherent to natural languages in general(More)
CAD systems have yet to become usable at the early stages of product ideation, where precise shape definitions and sometimes even design intentions are not fully developed. To overcome these limitations, new approaches, which we call Calligraphic Interfaces, use sketching as the main organizing paradigm. Such applications rely on continuous input modalities(More)
AIMS AND OBJECTIVES To examine the prevalence of aggression against healthcare professionals and to determine the possible impact that violent episodes have on healthcare professionals in terms of loss of enthusiasm and involvement towards work. The objective was to analyse the percentage of occupational assault against professionals' aggression in(More)
Current manufacturing scheduling has still difficulties to deal with real-world situations and, hence, human intervention is required to maintain real-time adaptation and optimization, to efficiently adapt to the inherent complex system dynamics. In this paper the prototype of an Adaptive Decision Support System for Interactive Scheduling with MetaCognition(More)
User modeling and user adaptive interaction has become a central research issue to understand users as they interact with technology. The importance of the development of well adapted interfaces to several kinds of users and the differences that characterize them is the basis of the successful interaction. User Personas is a technique that allows the(More)
User modeling and user adaptive interaction research areas are becoming crucial applied issues to understand and support users as they interact with technology. Modeling the decisions to be made and the constraints placed by market globalization in a way that can address the needs of all stakeholders has been a long time area of academic and industrial(More)
This paper describes error handling and ambiguity in a class of applications organized around drawing and sketching, which we call Calligraphic Interfaces. While errors and imprecision are unavoidable features of human input, these have long been considered nuisances and problems to circumvent in user interface design. However, the transition away from(More)