João Paulo Pereira

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A two-year-old female miniature poodle died unexpectedly while romping with its owner. Anomalous origin of the left coronary artery from the left pulmonic sinus was discovered at necropsy. Histologically, the right ventricle was unremarkable, but multifocal to coalescing necrosis and fibrosis occurred in the myocardium and endocardium of the left ventricle.(More)
CAD systems have yet to become usable at the early stages of product ideation, where precise shape definitions and sometimes even design intentions are not fully developed. To overcome these limitations, new approaches, which we call Calligraphic Interfaces, use sketching as the main organizing paradigm. Such applications rely on continuous input modalities(More)
BACKGROUND Psychological flexibility has been suggested as a fundamental process in health. The Psychological Inflexibility in Pain Scale (PIPS) is one of the scales employed for assessing psychological inflexibility in pain patients. The aim of this study was to validate the Spanish version of the PIPS and secondly, to compare it to two other psychological(More)
Buruli ulcer (BU) is a devastating, necrotizing, tropical skin disease caused by infections with Mycobacterium ulcerans. In contrast to other mycobacterioses, BU has been associated with minimal or absent inflammation. However, here we show that in the mouse M. ulcerans induces persistent inflammatory responses with virulence-dependent patterns.(More)
AIMS AND OBJECTIVES To examine the prevalence of aggression against healthcare professionals and to determine the possible impact that violent episodes have on healthcare professionals in terms of loss of enthusiasm and involvement towards work. The objective was to analyse the percentage of occupational assault against professionals' aggression in(More)
Throughout the last decade many approaches have been made to the problem of developing CAD systems that are usable in the early stages of product ideation. Although most of these approaches rely on some kind of drawing paradigm and on the paper-and-pencil metaphor, only a few of them deal with the ambiguity that is inherent to natural languages in general(More)
User modeling and user adaptive interaction has become a central research issue to understand users as they interact with technology. The importance of the development of well adapted interfaces to several kinds of users and the differences that characterize them is the basis of the successful interaction. User Personas is a technique that allows the(More)
This paper presents a generalized finite element method (GFEM) for crack growth simulations based on a two-scale decomposition of the solution – a smooth coarse-scale component and a singular fine-scale component. The smooth component is approximated by discretizations defined on coarse finite element meshes. The fine-scale component is approximated by the(More)
Sketch-based interfaces can provide a natural way for users to interact with applications. Since the core of a sketch-based interface is the gesture recognizer, there is a need to correctly evaluate various recognizers before choosing one. In this paper the authors present an evaluation of three gesture recognizers: Rubine’s recognizer, CALI and the $1(More)