João Cândido Fernandes

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Heavy metal pollution is one of the most troublesome environmental problems faced by mankind nowadays. Copper, in particular, poses serious problems due to its widespread industrial and agricultural use. Unlike other heavy metals, such as cadmium, lead, and mercury, copper is not readily bioaccumulated and thus its toxicity to man and other mammals is(More)
1 Institute for Polymers, Composites and Biomaterials, CNR, Via Campi Flegrei 34, 80078 Pozzuoli, Naples, Italy 2Institute for Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal 3French Research Institute for Exploitation of the Sea (IFREMER), Microbial Ecosystems and Marine Molecules for the(More)
A low-cost modular compact personal computer-based system for surface precordial mapping (SPM) developed by the authors was used to detect rejection periods, documented by endomyocardial biopsy (EB), in heart transplant patients on cyclosporine A therapy. Data were collected with a matrix of 35 Ag-AgCl electrodes positioned over the precordio with(More)
Erythroid hypoplasia (EH) is a rare complication associated with recombinant human erythropoietin (rHuEPO) therapies, due to development of anti-rHuEPO antibodies; however, the underlying mechanisms remain poorly clarified. Our aim was to manage a rat model of antibody-mediated EH induced by rHuEPO and study the impact on iron metabolism and erythropoiesis.(More)
* Specialist in Clinical and Educational Audiology at the Craniofacial Anomalies Rehabilitation Hospital of the University of São Paulo (HRAC-USP) and Master’s Degree in “General Bases of Surgery” at the Medicine College of the Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP campus Botucatu SP). Clinical Phonoaudiologist. ** Doctor’s Degree.(More)
A computerized Data Acquisition System conceived and built by LNETI/DEE in cooperation with Department of Cardiology of Hospital Santa Cruz, and its application to processing and representation of cardiac precordial maps (MAPCARD SYSTEM), was described. A description was made about the evolution on cardiac maps, their main areas of interest, pointing to(More)
A variable diameter trial liner (VDTL) was designed to reduce the costs related to cleaning, sterilisation and storage of surgical instruments used for total hip arthroplasty. The purpose of this study was to develop a finite element model to evaluate the mechanical behavior of the VDTL before manufacturing of a functional prototype. The finite element(More)
A variable diameter acetabular trial implant (VDATI) was designed to reduce the costs related to cleaning, sterilisation and storage of surgical instruments used for total hip arthroplasty. The purpose of this study was to evaluate the mechanical strength of a functional prototype of the VDATI. Experimental testing was performed to identify if the VDATI can(More)
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