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Caries is a multifactorial disease and little is still known about the host genetic factors influencing susceptibility. Our previous genome-wide linkage scan has identified the interval 5q12.1-5q13.3 as linked to low caries susceptibility in Filipino families. Here we fine-mapped this region in order to identify genetic contributors to caries(More)
AIM The purpose of this study was to evaluate the in vitro effect of Light Coke, phosphoric acid, and citric acid on the force decline pattern of two types of elastomeric chains. METHODS AND MATERIALS One hundred sixty gray colored elastomeric chain modules, 80 Chainette (GAC) and 80 Sunburst (GAC) chains, were divided into four groups for immersion into(More)
There is evidence for a genetic component in caries susceptibility, and studies in humans have suggested that variation in enamel formation genes may contribute to caries. For the present study, we used DNA samples collected from 1,831 individuals from various population data sets. Single nucleotide polymorphism markers were genotyped in selected genes(More)
Regarding host aspects, there has been strong evidence for a genetic component in the etiology of caries. The salivary protein lactotransferrin (LTF) exhibits antibacterial activity, but there is no study investigating the association of polymorphisms in the promoter region of LTF gene with caries. The objective of this study was firstly to search the(More)
OBJECTIVES To investigate the influence of clinical status and salivary conditions on the presence of xerostomia on adolescents with and without type 1 diabetes mellitus (DM1), and further to investigate the influence of clinical status, salivary conditions and xerostomia on oral health-related quality of life (OHQoL) of those with DM1. METHODS A(More)
OBJECTIVE The present study evaluated the association between lactotransferrin (LTF) gene polymorphism (exon 2, A/G, Lys/Arg) and dental caries. MATERIAL AND METHODS A convenience sample of 110 individuals, 12 years old, was divided into: group 1, 48 individuals without caries experience (DMFT=0), and group 2, 62 subjects with caries experience(More)
Caries is the most common chronic, multifactorial disease in the world today; and little is still known about the genetic factors influencing susceptibility. Our previous genome-wide linkage scan has identified five loci related to caries susceptibility: 5q13.3, 13q31.1, 14q11.2, 14q 24.3, and Xq27. In the present study, we fine mapped the 14q11.2 locus to(More)
OBJECTIVE To evaluate the impact of xerostomia on the quality of life (QOL) of adolescents with type 1 diabetes mellitus (DM1). STUDY DESIGN The sample was comprised of 51 adolescents with DM1. Diabetic status was determined by glycosylated hemoglobin (HbG) and capillary glucose (CG) tests. Poor metabolic control was defined as HbG >8.0% and CG <90 mg/dL(More)
The present study aimed to evaluate whether or not quantitative changes occur in the salivary flow of patients with chronic renal insufficiency (CRI) who have been submitted to Hemodialysis. Twenty-nine chronic renal patients, between 4 and 25 years of age, submitted to Hemodialysis at Hospital Pequeno Príncipe in Curitiba, Paraná, Brazil participated in(More)
Saliva components play a crucial role in the integrity of the dental enamel and in caries susceptibility. The saliva characteristics are controlled by many factors, including genetic factors. Therefore, this study aimed to evaluate the association between the genetic variations in genes expressed in enamel development with calcium and phosphorus levels in(More)