João Alvaro Carvalho

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Traditional approaches to requirements elicitation stress systematic and rational analysis and representation of organizational context and system requirements. This paper argues that the introduction of any computer-based system to an organization transforms the organization and changes the work patterns of the system's users in the organization. These(More)
The authors have shown in a recent paper that survival with amyotrophic lateral sclerosis (ALS) can be increased by the use of non-invasive methods of assisted ventilation (Bipap). However, the progression of muscle weakness was not affected and the quality of life was not positively enhanced. In ALS, reduced physical activity may partially be secondary to(More)
Traditional approaches to requirements elicitation stress systematic and rational analysis and representation of organizational context and system requirements. This paper argues that (1) for an organization , a software system implements a shared vision of a future work reality and that (2) understanding the emotions, feelings, values, beliefs, and(More)
Model-driven development (MDD) conceptions and techniques essentially centre the focus of development on models. They are subject of current research as they allow enhanced productivity, technological platform independence and longevity of software artifacts. Another area of current research is the ubiquitous/pervasive computing area. This field of(More)
The requirements definition needs attention to a number of issues related to the way people understand organisations, do their work and use the tools available to support that work. Most well-known requirements engineering methods focus on technical aspects of work. This paper proposes a way of looking at work situations in order to gain a deep(More)
Delocalized lipophilic cations (DLCs) penetrate plasma and mitochondrial membranes and accumulate in mito-chondria. The higher mitochondrial membrane potentials of neoplastic vs normal cells, in general, account for greater uptake and may be a way to selectively target these cells since. Dequalinium (DQA) is a DLC and so our goal is to evaluate the(More)