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The Bcl-2 family of proteins is the key regulators of cell apoptosis at the mitochondria level. The BH3-only pro-apoptotic member BclGs was unique among the family due to its highly specific expression in human testis and has been demonstrated to induce apoptosis dependent on the BH3 domain. However, the molecular mechanism of BclGs-induced apoptosis(More)
The venom peptides of cone snails are encoded by a large gene family, and can selectively bind to voltage-gated ion channels (Na⁺, K⁺ and Ca²⁺ channels) and to membrane receptors (nAChR, 5-HT3R, NMDAR). To identify novel conotoxin genes and analyze the evolution of typical conotoxin superfamily genes from different Conus species, we have constructed cDNA(More)
Development of a microsphere-based competitive fluorescence immunoassay for the determination of hazardous low-molecular-weight compounds in food is described. In this method, antigens are covalently bound to carboxy-modified microspheres to compete monoclonal antibody with low-molecular-weight compounds in food samples; mouse IgG/fluorescein isothiocyanate(More)
Growth factor receptor-bound protein 2 (Grb2) is an extensively studied adaptor protein involved in cell signaling. Grb2 is a highly flexible protein composed of a single SH2 domain flanked by two SH3 domains. The evolutionarily conserved serine/threonine kinase, AMP-activated protein kinase (AMPK), functions as a cellular fuel gauge that regulates(More)
In this study, a total of 255 isolates of Phytophthora infestans were collected from potato in Hebei, Liaoning, Jilin and Heilongjiang in 2008 and 2009. Twelve types of SSR genotypes were identified from 200 strains of P. infestans using two pairs of SSR primers, Pi4B and Pi4G. Among them, Genotype F-01 dominated population and accounted for 72.00%.(More)
OBJECTIVE Based on immunoassay, we developed a method to detect Potato Virus A (PVA) using one-step cytometric bead array (CBA). METHODS Using fluorescent beads as carriers, we formed the complexes of bead-capture antibody-PVA-fluoresceinisothiocyanate (FITC) labeled detection antibody by immunoreaction of double antibody sandwich on bead surface. We(More)
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