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  • John R. Cirrito, Jae-Eun Kang, Jiyeon Lee, Floy R. Stewart, Deborah K. Verges, Luz M. Silverio +3 others
  • 2008
Aggregation of amyloid-beta (Abeta) peptide into soluble and insoluble forms within the brain extracellular space is central to the pathogenesis of Alzheimer's disease. Full-length amyloid precursor protein (APP) is endocytosed from the cell surface into endosomes where it is cleaved to produce Abeta. Abeta is subsequently released into the brain(More)
The processing of amyloid precursor protein (APP) to Abeta is an important event in the pathogenesis of Alzheimer's disease, but the physiological function of APP is not well understood. Our previous work has shown that APP processing and Abeta production are regulated by the extracellular matrix protein Reelin. In the present study, we examined whether(More)
Studies evaluating phonological contrast learning typically investigate either the predictiveness of specific pretraining aptitude measures or the efficacy of different instructional paradigms. However, little research considers how these factors interact--whether different students learn better from different types of instruction--and what the(More)
This case study investigated patterns of interaction and participation in a large online course. 88 Korean undergraduates participated in online fora during 2 weeks. It was found that there was a comparatively high portion of metacognitive interaction and higher phase of knowledge construction. However, it was found that students posted required number of(More)
OBJECTIVE The purpose of this review of students with attention deficit hyperactivity disorder (ADHD) was to summarize the following: (1) academic deficits in math and reading, (2) possible theoretical contributors to these deficits, and (3) psychostimulant interventions that target math and reading, as well as, parallel interventions involving sensory(More)
— Over recent years, mobile Internet devices such as laptops, PDAs, smart phones etc, have become extremely popular and widespread. Once on board of a vehicle, these devices can automatically connect to the vehicle processor and thus greatly amplify the communications and processing capabilities available to the owner in a " pedestrian mode. " We envision(More)
Accumulation of extracellular amyloid beta peptide (Abeta), generated from amyloid precursor protein (APP) processing by beta- and gamma-secretases, is toxic to neurons and is central to the pathogenesis of Alzheimer disease. Production of Abeta from APP is greatly affected by the subcellular localization and trafficking of APP. Here we have identified a(More)
Low-density lipoprotein receptor-related protein 1 (LRP1) is an endocytic recycling receptor with two cytoplasmic tyrosine-based basolateral sorting signals. Here we show that during biosynthetic trafficking LRP1 uses AP1B adaptor complex to move from a post-TGN recycling endosome (RE) to the basolateral membrane. Then it recycles basolaterally from the(More)
A mixed-criticality system consists of multiple components with different criticalities. While mixed-criticality scheduling has been extensively studied for the uniprocessor case, the problem of efficient scheduling for the multiprocessor case has largely remained open. We design a fluid model-based multiprocessor mixed-criticality scheduling algorithm,(More)
The paper reports findings derived from three experiments examining syntactic and morphosyntactic processing in individuals with agrammatic and logopenic variants of primary progressive aphasia (PPA-G and PPA-L, respectively) and stroke-induced agrammatic and anomic aphasia (StrAg and StrAn, respectively). We examined comprehension and production of(More)