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Interleukin-2-inducible T-cell kinase (Itk) is a member of the Btk (Bruton's tyrosine kinase) family of tyrosine kinases. Itk plays an important role in normal T-cell functions and in the pathophysiology of both autoimmune diseases and T-cell malignancies. Here, we describe the initial characterization of a selective inhibitor,(More)
An L-segment consists of a horizontal and a vertical straight line which form an L. In an L-embedding of a graph, each vertex is represented by an Lsegment, and two segments intersect each other if and only if the corresponding vertices are adjacent in the graph. If the corner of each L-segment in an Lembedding lies on a straight line, we call it a monotone(More)
We established a cell based high throughput screening model by calcium assay on fluorometric imaging plate reader for finding modulators of TRPV3. The TRPV3 expression vector was transfected into HEK-293 and stable cell line expressing TRPV3 was selected with antibiotics. Upon TRPV3 specific modulators stimulated, pharmacological characteristics of TRPV3(More)
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