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The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis
Insight is provided into the structural changes that occur when RIP kinases are triggered to execute different signaling outcomes and the realm of amyloids is expanded to complex formation and signaling.
Structural biology of innate immunity.
Recent progress in mechanistic delineation of proteins in innate immunity pathways, their structural features, modes of ligand recognition, conformational changes, and homo- and hetero-oligomeric interactions within the supramolecular complexes are reviewed.
Structural Insights into the Assembly of Large Oligomeric Signalosomes in the Toll-Like Receptor–Interleukin-1 Receptor Superfamily
The potential mechanisms of step-by-step assembly from the membrane-proximal interactions to the more downstream events are illustrated and formation of large oligomeric signalosomes may help to establish a digital threshold response in TLR and IL-1R signaling.
Structural basis of signal transduction in the TNF receptor superfamily.
It is revealed that upon ligand binding, multiple intracellular proteins form higher-order signaling machines to transduce and amplify receptor activation information to different cellular fates, including NF-κB activation, apoptosis, and programmed necrosis.
A Novel Halotolerant Thermoalkaliphilic Esterase from Marine Bacterium Erythrobacter seohaensis SW-135
- Ying-yi Huo, Zhen Rong, Shu-Ling Jian, Cao Xu, Jixi Li, Xue-Wei Xu
- Biology, MedicineFront. Microbiol.
- 22 November 2017
The results of this study provide insight into marine alkaliphilic esterases, and the unique properties of E69 make it a promising candidate as a biocatalyst for industrial applications.
Deacetylation of serine hydroxymethyl-transferase 2 by SIRT3 promotes colorectal carcinogenesis
The authors show that acetylation of the lysine-95 (K95) residue negatively regulates SHMT2 expression and activity and is deacetylated by SIRT3 in colorectal cancer.
Peptidoglycan‐Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF‐&kgr;B Signaling
Amyloid formation involves a motif resembling one found in necroptosis‐associated mammalian proteins and can be negatively regulated, suggesting that amyloidal signaling platforms may present a regulatory point in multiple biological processes.
Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP.
- Jixi Li, Zhiyi Wei, +8 authors Y. Mao
- Chemistry, MedicineJournal of molecular biology
- 2 September 2005
The first crystal structure of human GMP reductase 2 in complex with GMP at 3.0 A resolution is reported, and it is proposed that Cys186 is the potential active site, and that the conformation of the loop suggests a preference for the coenzyme NADPH over NADH.
The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex
The RIPK1-RIPK3 core is the first detailed structure of a hetero-amyloid and provides a potential explanation for the specificity ofhetero- over-homo-AMyloid formation and a structural basis for understanding the mechanisms of signal transduction.
Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis
- Siyun Kuang, Jun Zheng, +7 authors Jixi Li
- Biology, MedicineProceedings of the National Academy of Sciences
- 19 September 2017
The crystal structure of the C-terminal domain of human GSDMD (GSDMD-C) is determined and it is determined that one short segment is sufficient to kill bacteria in vitro and can efficiently inhibit cell growth in Escherichia coli and Mycobacterium Smegmatis.