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BACKGROUND Chemoresistance is a main obstacle to effective esophageal cancer (EC) therapy. We hypothesize that altered expression of microRNAs (miRNAs) play a role in EC cancer progression and resistance to 5-fluorouracil (5-FU) based chemotherapeutic strategies. METHODS Four pairs of esophageal adenocarcinoma (EAC) cell lines and corresponding 5-FU(More)
Aiming at compensating the lack of affect interaction between teachers and students in e-Learning systems/environments, this paper presents an architecture of interactive text-oriented affect compensation Mechanism in e-Learning. Based on which, a hierarchical emotion regulation agent (ERA) is proposed to perceive the emotion state of an individual or group(More)
The formation of cognitive system usually accompanies the change of emotions that play a significant role in cognitive process of humankind. Emotion affected by internal elements and external stimulations in various contexts is a complex psychological experience and physiological expression of human being. In this paper, we focus primarily on the evaluation(More)
E-learning provides an unprecedented flexibility and convenience for e-learners by breaking the limitations of space and time. However, the role of emotion is neglected in current e-learning systems. We focus strictly on negative emotions of e-learners, integrating emotion regulation theories with recommender technique, and present the study of(More)
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