Jithangi Wanigasinghe

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A 14-year-old boy presented with acute paraparesis with sensory and sphincter disturbance. Imaging and neurophysiologic studies were diagnostic for transverse myelitis with acute motor axonal neuropathy. He was treated with both intravenous immunoglobulin and high-dose corticosteroids, and he made a slow and incomplete recovery. Acute motor axonal(More)
An outbreak of Aspergillus fumigatus meningitis occurred in 5 women following spinal anaesthesia, performed between 21 June and 17 July 2005 for caesarean section, in Colombo, Sri Lanka. The patients' median age was 27 years. Different teams in 2 maternity hospitals gave spinal anaesthesia. Mean incubation period was 11.2 days. Fever, headache and nuchal(More)
AIM The aim of this study was to describe the frequency, risk factors, manifestations, and outcome of epilepsy in children with hemiplegic cerebral palsy (CP) due to perinatal arterial ischaemic stroke (AIS). METHOD The study group comprised 63 participants (41 males, 22 females) from a population-based CP register whose brain imaging showed perinatal(More)
PURPOSE We created an epilepsy patient database that can be accessed via the Internet by neurologists from anywhere in the world. The database was designed to enroll and follow large cohorts of patients with specific epilepsy syndromes, and to facilitate recruitment of patients for investigator-initiated clinical trials. METHODS The EpiNet database(More)
OBJECTIVE A single-center, single-blind, parallel-group, randomized clinical trial was performed to test the null hypothesis that adrenocorticotropic hormone is not superior to high-dose prednisolone for treatment of newly diagnosed West syndrome. METHODS Newly diagnosed infants with West syndrome were randomized to receive 14 days of oral prednisolone(More)
BACKGROUND The role of therapy on improvement of hypsarrhythmia has not been systematically assessed. This study was performed to assess the efficacy of oral prednisolone and intramuscular adrenocorticotrophin hormone in improving hypsarrhythmia in West syndrome. METHOD Children (2 months-2 years), with previously untreated West syndrome, were randomized(More)
The recent recognition of anti-N-methyl-D-aspartate receptor (NMDAR) antibody encephalitis has added to the growing list of treatment-responsive, reversible, autoimmune CNS disorders [1]. NMDAR-antibody encephalitis is characterised by a multistage progression from psychosis, memory deficits, seizures and language dysfunction to a state of coma often(More)
We report three symptomatic children with profound biotinidase deficiency from Sri Lanka. All three children presented with typical clinical features of the disorder. The first is homozygous for a missense mutation in the BTD gene (c.98_104 del7insTCC; p.Cys33PhefsX36) that is commonly seen in the western countries, the second is homozygous for a novel(More)
Method A retrospective cohort study was performed on 205 children aged 1−12 years presented to a tertiary care hospital in Sri Lanka;119 with epilepsy, exposed to AEDs more than 2 years and 86 who are unexposed to AED. Vitamin D levels and bone profile were analyzed by chemiluminescent auto analyzer and photometric methods respectively. The prevalence of(More)