Jitendra Barupal

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Background Reduced representation bisulfite sequencing (RRBS) is an efficient approach for large-scale base-pair resolution DNA methylation analysis. RRBS utilizes Mspl digestion to enrich for CpG dinucleotides prior to sequencing. RRBS works with considerably lower amounts of DNA compared to the human 450K BeadChip Illumina microarray. Previous studies(More)
There is compelling evidence that particulate matter (PM) increases lung cancer risk by triggering systemic inflammation, and leukocyte DNA hypomethylation. However, previous investigations focused on repeated element sequences from LINE-1 and Alu families. Tandem repeats, which display a greater propensity to mutate, and are often hypomethylated in cancer(More)
BACKGROUND MicroRNAs (miRNAs) are post-transcriptional gene suppressors and potential mediators of environmental effects. In addition to human miRNAs, viral miRNAs expressed from latent viral sequences are detectable in human cells. OBJECTIVE In a highly exposed population in Beijing, China, we evaluated the associations of particulate air pollution(More)
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