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BACKGROUND Cardiovascular disease is the leading cause of death among those with diabetes mellitus. Vitamin D deficiency is associated with an increased risk of cardiovascular disease in this population. To determine the mechanism by which vitamin D deficiency mediates accelerated cardiovascular disease in patients with diabetes mellitus, we investigated(More)
It is challenging to process transactions in a timely fashion using fresh data, e.g., current stock prices, since database workloads may considerably vary due to dynamic data/resource contention. Further, transaction timeliness and data freshness requirements may compete for system resources. In this paper, we propose a novel feedback control model to(More)
Multiple epidemiological studies link vitamin D deficiency to increased cardiovascular disease (CVD), but causality and possible mechanisms underlying these associations are not established. To clarify the role of vitamin D-deficiency in CVD in vivo, we generated mouse models of diet-induced vitamin D deficiency in two backgrounds (LDL receptor- and(More)
Reduced monocyte infiltration into the vessel wall and increased macrophage cholesterol efflux are critical components in atherosclerotic plaque regression. During inflammation, monocyte chemotactic protein 1 (MCP-1) signaling activation and cholesterol deposition in macrophages induce endoplasmic reticulum (ER) stress, which promotes an increased(More)
Real-time data services can benefit data-intensive real-time applications, e.g., e-commerce, via timely transaction processing using fresh data, e.g., the current stock prices. To enhance the real-time data service quality, we present several novel techniques for (1) database backlog estimation, (2) fine-grained closed-loop admission control based on the(More)
A lot of real-time database (RTDB) research has been done to process transactions in a timely fashion using fresh data reflecting the current real world status. However, most existing RTDB work is based on simulations. Due to the absence of a publicly available RTDB testbed, it is very hard to evaluate real-time data management techniques in a realistic(More)
It is essential to process real-time data service requests such as stock quotes and trade transactions in a timely manner using fresh data, which represent the current real-world phenomena such as the stock market status. Users may simply leave when the database service delay is excessive. Also, temporally inconsistent data may give an outdated view of the(More)
It is challenging to manage the performance of real-time databases (RTDBs) that are often used in data-intensive real-time applications such as agile manufacturing and target tracking. Feedback control has recently been considered a promising approach to enabling reliable real-time data service. However, most existing work on feedback control of RTDB(More)
Cardiovascular disease (CVD) is the leading cause of mortality in patients with type 2 diabetes mellitus (T2DM). Vitamin D deficiency is not only more prevalent in diabetics but also doubles the risk of developing CVD. However, it is unknown whether 25-hydroxy vitamin D [25(OH)D3] replacement slows monocyte adhesion and migration, critical mechanisms(More)
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). In type 2 diabetics, the prevalence of vitamin D deficiency is 20% higher than in non-diabetics, and low vitamin D levels nearly double the relative risk of developing CVD compared to diabetic patients with normal vitamin D levels.(More)