Jiro Kimura

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We attempted to detect natural mutations existing in the Jcl:ICR closed colony of mice which is maintained by random mating. We used ordinary genetic backcrosses to efficiently detect recessive mutations carried by individual mice in the colony. Crosses of DBA/2 females and ICR males were performed to obtain F(1) mice. Four F(1) females randomly selected(More)
We developed a new software named TEICTDM based on the Bayesian estimation utilized in the therapeutic drug monitoring (TDM) of teicoplanin, a glycopeptide antibiotic, for the estimation of individual pharmacokinetic parameters. Therefore, it is necessary to input more than one plasma concentration(s) determined in individual patient. Individual(More)
Peutz-Jeghers syndrome (PJS) is a rare condition characterized by autosomal dominant inheritance, mucocutaneous pigmentation, and gastrointestinal hamartomatous polyps, and is a subtype of hereditary gastrointestinal polyposis. Among PJS, there is no difference of incidence among race and sex, and the incidence has been estimated to be 1 in 120,000–150, 000(More)
We developed a new software (Ver. 2.0) based on the Bayesian estimation utilized in the therapeutic drug monitoring (TDM) of teicoplanin, a glycopeptide antibiotic, for the estimation of individual pharmacokinetic parameters. Individual pharmacokinetic parameters were calculated by a least squares methods, MULTI2 (BAYES), and a two-compartment model with(More)
INTRODUCTION Yersinia pseudotuberculosis infection is usually cured spontaneously or with administration of antibiotics. PRESENTATION OF CASE The patient is a twelve-year-old boy with right lower quadrant pain who had enterocolitis one month previously. Contrast-enhanced abdominal computed tomography showed a distended and edematous ileum and an(More)
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