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Reactive Oxygen Species Mediate Caspase Activation and Apoptosis Induced by Lipoic Acid in Human Lung Epithelial Cancer Cells through Bcl-2 Down-Regulation
TLDR
A novel pro-oxidant role of LA is indicated in apoptosis induction and its regulation by Bcl-2, which may be exploited for the treatment of cancer and related apoptosis disorders.
Development of piperic acid derivatives from Piper nigrum as UV protection agents
TLDR
From the results, isopropyl piperate is an outstanding compound that can be developed into a UV protection agent.
Reactive Oxygen Species Mediate Caspase Activation and Apoptosis Induced by Lipoic Acid in Human Lung Epithelial Cancer Cells through Bcl-2 Downregulation
TLDR
It is reported here that LA induced reactive oxygen species (ROS) generation and a concomitant increase in apoptosis of human lung epithelial cancer H460 cells, indicating a novel pro-oxidant role of LA in apoptotic induction and its regulation by Bcl-2, which may be exploited for the treatment of cancer and related apoptosis disorders.