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Foxp3(+)CD4(+)CD25(high) regulatory T cell (Treg) suppression of inflammation depends on T-cell receptor-mediated Nuclear Factor of Activated T cells c1 (NFATc1) activation with reduced Akt activity. We investigated the role of the scaffold protein Disc large homolog 1 (Dlgh1) in linking the T-cell receptor to this unique signaling outcome. The Treg(More)
This study was aimed to determine the role and regulation of progranulin (PGRN) in the pathogenesis of inflammatory bowel diseases (IBD). Dextran sulfate sodium (DSS)-, picrylsulfonic acid (TNBS)-induced, bone marrow chimera and CD4+CD45Rb(hi) T cell transfer colitis model were established and analyzed in wild-type and several genetically-modified mice,(More)
Regulatory T-cell (Treg) selection in the thymus is essential to prevent autoimmune diseases. Although important rules for Treg selection have been established, there is controversy regarding the degree of self-reactivity displayed by T-cell receptors expressed by Treg cells. In this study we have developed a model of autoimmune skin inflammation, to(More)
Neurofilament protein-L (NF-L) is the core component of neurofilaments. Recent studies indicate that the NF-L mutations reported in human Charcot-Marie-Tooth (CMT) disease lead to the formation of NF-L aggregates and result in axon degeneration of motor and sensory neurons, which are thought to be the cause of CMT disease type 2E. In the present study, we(More)
This paper develops a color image recovery system from a color-embedded gray image. A reversible color-to-gray algorithm is an effective technique from several viewpoints such as running cost, data quantity, and security in practical applications. Most of the conventional algorithms work only on electronic gray images in the closed computer world, and do(More)
The ADAMTS proteinases are a group of multidomain and secreted metalloproteinases containing the thrombospondin motifs. ADAMTS-7 is a member of ADAMTS family and plays a crucial role in the pathogenesis of arthritis. Overexpression of ADAMTS-7 gene promotes the breakdown of cartilage oligomeric matrix protein (COMP) matrix and accelerates the progression of(More)
14-3-3 Proteins Interact with Neurofilament Protein-L (NF-L) and Regulate Dynamic Assembly of Neurofilaments Linqing Miao, Junlin Teng, Jiqiang Lin, Xianzhi Liao and Jianguo Chen 2 * 1 The State Key Laboratory of Bio-membrane and Membrane Bio-engineering, and The Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, College of(More)
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