• Publications
  • Influence
Prognostic value of matrix metalloproteinases (MMP-2 and MMP-9) in patients with lymph node-negative breast carcinoma
  • H. Li, D. Cao, +10 authors Z. Shao
  • Medicine
  • Breast Cancer Research and Treatment
  • 1 November 2004
TLDR
It is concluded that M MP-2 and MMP-2 are unfavorable prognostic factors in breast cancer patients and might be potential predictive factor for adjuvant systemic therapy. Expand
Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer
TLDR
Overexpression of peroxiredoxin 6 leads to a more invasive phenotype and metastatic potential in human breast cancer, at least in part, through regulation of the levels of uPAR, Ets-1, MMP-9, RhoC and TIMP-2 expression. Expand
Breast cancer in a transitional society over 18 years: trends and present status in Shanghai, China
TLDR
It is observed that breast cancer incidence increased dramatically over the past 30 years and documented a peak incidence represented by the middle-age group (45–59 years), which emerged in the last 20 years. Expand
The prevalence of PALB2 germline mutations in BRCA1/BRCA2 negative Chinese women with early onset breast cancer or affected relatives
TLDR
The results suggested that a detection of exon 4 before the assay of the whole PALB2 gene might be a cost-effective approach to the screening of Chinese population. Expand
Fiberoptic ductoscopy for patients with nipple discharge
TLDR
F Fiberoptic ductoscopy (FDS) is an emerging technique allowing direct visual access to the ductal system of the breast through nipple orifice exploration. Expand
An Elevated Peripheral Blood Lymphocyte-to-Monocyte Ratio Predicts Favorable Response and Prognosis in Locally Advanced Breast Cancer following Neoadjuvant Chemotherapy
TLDR
An elevated pre-NCT peripheral LMR level was a significantly favorable factor for locally advanced breast cancer patient prognosis, suggesting this easily obtained variable may serve as a valuable marker to predict the outcomes of locallyAdvanced breast cancer. Expand
Identification of breast cancer metastasis‐associated proteins in an isogenic tumor metastasis model using two‐dimensional gel electrophoresis and liquid chromatography‐ion trap‐mass spectrometry
TLDR
A highly metastatic variant of human MDA‐MB‐435 breast cancer cell line is developed through in in vivo stepwise selection of pulmonary metastatic cells caused by parental Mda‐ MB‐435 cells in the athymic mice. Expand
Comprehensive transcriptome analysis identifies novel molecular subtypes and subtype-specific RNAs of triple-negative breast cancer
TLDR
A novel TNBC classification system integrating the expression profiles of both mRNAs and lncRNAs is developed and determined subtype-specific lnc RNAs that are potential biomarkers and targets that could facilitate patient counseling and individualize treatment of TNBC. Expand
Genetic variants in GSTM3 gene within GSTM4-GSTM2-GSTM1-GSTM5-GSTM3 cluster influence breast cancer susceptibility depending on GSTM1
  • K. Yu, L. Fan, +8 authors Z. Shao
  • Biology, Medicine
  • Breast Cancer Research and Treatment
  • 1 June 2010
TLDR
It is inferred that GSTM3 catalyzing ability in normal breast tissue might protect against breast carcinogenesis and SNPs/haplotypes in the GSTm3 gene within the GSTMs gene cluster are likely to contribute to breast cancer risk when the GSTM1 is absent. Expand
ERα negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor
  • J. Fan, W. Yin, +6 authors Z. Shao
  • Biology, Medicine
  • Journal of Cancer Research and Clinical Oncology
  • 9 February 2008
TLDR
The data indicate that DNMT1 inhibitor AZA and HDAC inhibitor TSA play important roles in restoring sensitivity of the ERα negative breast cancer cells to endocrine therapy in vitro and in vivo. Expand
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