Jinzhao Wang

  • Citations Per Year
Learn More
AIMS Cyclophosphamide, the precursor to the active 4-hydroxycyclophosphamide, is used in active glomerulonephritis despite limited pharmacokinetics data. The pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide were evaluated. The influence of laboratory and pharmacogenomic covariates on pharmacokinetics was evaluated as a secondary aim. (More)
BACKGROUND Mycophenolic acid (MPA) is used off-label to treat many forms of glomerulonephritis. OBJECTIVE To evaluate the pharmacokinetics of MPA and its glucuronide (MPAG) in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis patients with renal manifestations and to determine the effects of clinical (urinary protein excretion, serum(More)
The role of pharmacogenomics, clinical and demographic parameters in pharmacokinetic predictions was evaluated in patients receiving mycophenolic acid (MPA). A cohort study design of patients with glomerulonephritis secondary to lupus nephritis and anti-neutrophil cytoplasmic antibody (ANCA) vasculitis was employed. Forty-six patients with lupus nephritis(More)
STUDY OBJECTIVE This study was designed to prospectively evaluate the in vivo activities of drug transporters, metabolizing enzymes, and pharmacokinetics in patients with chronic kidney diseases (CKD) caused by glomerulonephritis and nonglomerular etiologies. DESIGN A prospective study design. PARTICIPANTS Eighteen adults with CKD. SETTING General(More)
Molecular dynamics simulation is an important method for the research of thermophysics. But it is difficult to implement the simulation with traditional serial algorithms because of a complex numerical calculation. A cluster-based spatial decomposition algorithm for solving large-scale Molecular Dynamics simulation of thermophysics is proposed in this(More)
OBJECTIVE Leukocyte mRNA expression patterns of drug metabolizing enzyme genes and transporter genes that are relevant for the disposition of cyclophosphamide and mycophenolate were studied. The relationships between expression and patient-level data and pharmacokinetics were evaluated. METHODS The study included patients with glomerulonephritis secondary(More)
Customer complaint has been the important feedback for modern enterprises to improve their product and service quality as well as the customer's loyalty. As one of the commonly used manners in customer complaint, telephone communication carries rich emotional information of speeches, which provides valuable resources for perceiving the customer's(More)
We present a novel algorithm for optimizing the order in which Chinese characters are learned, one that incorporates the benefits of learning them in order of usage frequency and in order of their hierarchal structural relationships. We show that our work outperforms previously published orders and algorithms. Our algorithm is applicable to any scheduling(More)
  • 1