Jinyue Liao

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Spermatogenic failure is a major cause of male infertility, which affects millions of couples worldwide. Recent discovery of long non-coding RNAs (lncRNAs) as critical regulators in normal and disease development provides new clues for delineating the molecular regulation in male germ cell development. However, few functional lncRNAs have been characterized(More)
Coordination of cell division timing is crucial for proper cell fate specification and tissue growth. However, the differential regulation of cell division timing across or within cell types during metazoan development remains poorly understood. To elucidate the systems-level genetic architecture coordinating division timing, we performed a high-content(More)
Ten eleven translocation (Tet) family-mediated DNA oxidation on 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) represents a novel epigenetic modification that regulates dynamic gene expression during embryonic stem cells (ESCs) differentiation. Through the role of Tet on 5hmC regulation in stem cell development is relatively defined, how the Tet(More)
Supplementary Movie 1. A 3D projection movie (ventral view with anterior to the left) produced with raw 4D images showing embryogenesis of a wild-type developing embryo from 4-cell to comma stage. The red 3D projection was generated with fluorescence micrographs of the lineaging markers while the green 3D projection was built from those of PHA-4::GFP.(More)
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