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INTRODUCTION Increasing evidence indicates that microRNAs (miRNAs) play a critical role in the pathogenesis of inflammatory diseases. The aim of the study was to investigate the expression pattern and function of miRNAs in CD4+ T cells from patients with rheumatoid arthritis (RA). METHODS The expression profile of miRNAs in CD4+ T cells from synovial(More)
BACKGROUND Fucoidan is a sulfated polysaccharide derived from brown algae that has been reported to perform multiple biological activities, including antitumor activity. In this study, we examined the influence of crude fucoidan on mouse breast cancer in vitro and in vivo. MATERIALS AND METHODS In vitro, fluorescent staining, flow cytometry and Western(More)
Understanding the genetic basis of Rubisco activase (RCA) gene regulation and altering its expression levels to optimize Rubisco activation may provide an approach to enhance plant productivity. However, the genetic mechanisms and the effect of RCA expression on phenotype are still unknown in soybean. This work analysed the expression of RCA genes and(More)
Prognostic and health monitoring (PHM) is the latest development of large complex equipment management. An extensible distributed prognostic and health monitoring system based on hybrid wireless network techniques was studied and designed in this paper. Firstly,after a careful analysis on the structure and tasks of the equipment, the general PHM framework(More)
The activating/co-stimulatory receptor NKG2D (natural-killer group 2, member D) is expressed on the surface of all human NK, NKT, CD8(+) T, and subsets of γδ(+) T cells. The significance of NKG2D function in tumor immunity has been well demonstrated in experimental animal models. However, the role of human NKG2D ligands in regulating tumor immunity and(More)
In order to improve the efficiency of regression testing, many test selection techniques have been proposed to extract a small subset from a huge test suite, which can approximate the fault detection capability of the original test suite for the modified code. This paper presents a new regression test selection technique by clustering the execution profiles(More)
Animal and cell experiments showed that inositol hexaphosphate (IP6) was protective on neurons in parkinson's disease (PD) model, but the underlying mechanism of this action was not extensively elucidated. To address this question, we established 6-hydroxydopamine (6-OHDA) induced human dopaminergic cell line SH-SY5Y as PD cell model and testified the(More)
Although Th22 and Th17 cells have been reported to play critical roles during autoimmunity and inflammation, information on their role in cancer-immunity is limited. In this study, we investigated clinical relevance of circulating Th22 and Th17 cells in patients with gastric cancer (GC). Using multi-color flow cytometry and PMA stimulation, we determined(More)
The paper presents a novel concept of lightweight and inherently safe robotic systems for assisting the locomotion recovery therapy and training. This concept, referred to as STRING-MAN, is established on string-puppet idea and utilizes modular wire robot components and advanced artificial muscles drives. An overview of the system's fundamental components,(More)
Most IP-geolocation mapping schemes [14], [16], [17], [18] take delay-measurement approach, based on the assumption of a strong correlation between networking delay and geographical distance between the targeted client and the landmarks. In this paper, however, we investigate a large region of moderately connected Internet and find the delay-distance(More)