Jinyan Liu

Dan H. Barouch7
Peter Abbink6
7Dan H. Barouch
6Peter Abbink
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  • Jinyan Liu, Kara L. O’Brien, Diana M. Lynch, Nathaniel L. Simmons, Annalena La Porte, Ambryice M. Riggs +13 others
  • 2009
A recombinant adenovirus serotype 5 (rAd5) vector-based vaccine for HIV-1 has recently failed in a phase 2b efficacy study in humans. Consistent with these results, preclinical studies have demonstrated that rAd5 vectors expressing simian immunodeficiency virus (SIV) Gag failed to reduce peak or setpoint viral loads after SIV challenge of rhesus monkeys(More)
  • Dan H. Barouch, Jinyan Liu, Hualin Li, Lori F. Maxfield, Peter Abbink, Diana M. Lynch +20 others
  • 2012
Preclinical studies of human immunodeficiency virus type 1 (HIV-1) vaccine candidates have typically shown post-infection virological control, but protection against acquisition of infection has previously only been reported against neutralization-sensitive virus challenges. Here we demonstrate vaccine protection against acquisition of fully heterologous,(More)
Human immunodeficiency virus type 1 (HIV-1)-specific monoclonal antibodies with extraordinary potency and breadth have recently been described. In humanized mice, combinations of monoclonal antibodies have been shown to suppress viraemia, but the therapeutic potential of these monoclonal antibodies has not yet been evaluated in primates with an intact(More)
The viral reservoir represents a critical challenge for human immunodeficiency virus type 1 (HIV-1) eradication strategies. However, it remains unclear when and where the viral reservoir is seeded during acute infection and the extent to which it is susceptible to early antiretroviral therapy (ART). Here we show that the viral reservoir is seeded rapidly(More)
  • Dan H. Barouch, Kathryn E. Stephenson, Erica N. Borducchi, Kaitlin Smith, Kelly Stanley, Anna G. McNally +24 others
  • 2013
The global diversity of HIV-1 represents a critical challenge facing HIV-1 vaccine development. HIV-1 mosaic antigens are bioinformatically optimized immunogens designed for improved coverage of HIV-1 diversity. However, the protective efficacy of such global HIV-1 vaccine antigens has not previously been evaluated. Here, we demonstrate the capacity of(More)
To the Editor Transcutaneous drug delivery from planar skin patches is effective for small-molecule drugs and skin-permeable vaccine adjuvants. 1 However, to achieve efficient delivery of vaccines and other macromolecular therapeutics into the skin, new technologies based on skin patches bearing arrays of micron-scale projections ('microneedles') are under(More)
Spider venom comprises a mixture of compounds with diverse biological activities, which are used to capture prey and defend against predators. The peptide components bind a broad range of cellular targets with high affinity and selectivity, and appear to have remarkable structural diversity. Although spider venoms have been intensively investigated over the(More)
Esophageal squamous cell carcinoma (ESCC) is a very common malignant tumor with poor prognosis in China. Chemokines secreted by tumors are pivotal for the accumulation of CD8(+) T lymphocytes within malignant lesions in several types of cancers, but the exact mechanism underlying CD8(+) T lymphocyte homing is still unknown in ESCC. In this study, we(More)
Cylindrocladium leaf blight is one of the most important diseases in Eucalyptus plantations. We investigated the proteome and transcriptome of Eucalyptus infected or not infected with Calonectria pseudoreteaudii. Here we provide the information about the processing of raw data obtained by RNA-seq and iTRAQ technologies. The data are related to [1].
We previously observed that Turnip mosaic virus (TuMV) induces systemic necrosis in Arabidopsis ecotype Ler but not in Col-0. Sharing most of the common features of the hypersensitive reaction, this systemic necrosis has been found to be a result of a gene-for-gene interaction between the host TuNI gene and viral P3 gene. We here analyzed the TuNI locus in(More)