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LRP6 dimerization through its LDLR domain is required for robust canonical Wnt pathway activation.
Canonical Wnt/β-catenin signaling pathway plays important roles in multiple aspects of cellular responses in development and diseases. It is currently thought that Wnt receptor Frizzled (Frz) exists… Expand
LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis.
How Wnt signalling including canonical and non-canonical pathways are initiated at the cell surface is not completely understood. Here we report that Wnt receptor Frizzled (Frz) and theco-receptors… Expand
Opposing Roles of Wnt Inhibitors IGFBP-4 and Dkk1 in Cardiac Ischemia by Differential Targeting of LRP5/6 and &bgr;-catenin
Background: Myocardial infarction is one of the leading causes of morbidity and mortality worldwide, triggering irreversible myocardial cell damage and heart failure. The role of low-density… Expand
Baicalin alleviates H2O2‑induced injury of H9c2 cardiomyocytes through suppression of the Wnt/β‑catenin signaling pathway.
- Liman Qiu, Jinxiao Chen, J. Lin, Da Wo, Jian-feng Chu, J. Peng
- Biology, Medicine
- Molecular medicine reports
- 1 December 2017
Baicalin is one of the active ingredients extracted from the dry root of Scutellaria baicalensis Georgi, which has been reported to be effective in preventing myocardial ischemia reperfusion injury.… Expand
IGFBP‐4 enhances VEGF‐induced angiogenesis in a mouse model of myocardial infarction
- Da Wo, Jinxiao Chen, +6 authors Dan-ni Ren
- Journal of cellular and molecular medicine
- 28 June 2020
Vascular endothelial growth factor (VEGF) is a well‐known angiogenic factor, however its ability in promoting therapeutic angiogenesis following myocardial infarction (MI) is limited. Here, we aimed… Expand
LRP6 Ectodomain Prevents SDF-1/CXCR4-Induced Breast Cancer Metastasis to Lung
Purpose: Lung metastasis is an important cause of breast cancer–related deaths, in which SDF-1/CXCR4 signaling pathway plays a critical role. Single transmembrane protein LRP6 is viewed as an… Expand
Deletion of low-density lipoprotein-related receptor 5 inhibits liver Cancer cell proliferation via destabilizing Nucleoporin 37
- Jinxiao Chen, Da Wo, +5 authors Dan-ni Ren
- Chemistry, Medicine
- Cell Communication and Signaling
- 1 December 2019
BackgroundLRP5/6 are co-receptors in Wnt/β-catenin pathway. Recently, we discovered multiple β-catenin independent functions of LRP5/6 in tumor cells and in the diseased heart. Nucleoporin 37 (NUP37)… Expand