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A correct alignment is an essential requirement in homology modeling. Yet in order to bridge the structural gap between template and target, which may not only involve loop rearrangements, but also shifts of secondary structure elements and repacking of core residues, high-resolution refinement methods with full atomic details are needed. Here, we describe(More)
A group key agreement protocol is designed to efficiently implement secure mul-ticast channels for a group of parties communicating over an untrusted, open network by allowing them to agree on a common secret key. In the past decade many problems related to group key agreement have been tackled and solved (diminished if not solved), and recently some(More)
A group key agreement protocol is designed to efficiently implement secure mul-ticast channels for a group of parties communicating over an untrusted, open network by allowing them to agree on a common secret key. In the past decade many problems related to group key agreement have been tackled and solved (diminished if not solved), and recently some(More)
BACKGROUND Prone positioning for acute respiratory distress syndrome (ARDS) has no impact on mortality despite significant improvements in oxygenation. However, a recent trial demonstrated reduced mortality rates in the prone position for severe ARDS. We evaluated effects of prone position duration and protective lung strategies on mortality rates in ARDS.(More)
BACKGROUND/AIMS Complete endotracheal tube obstruction is a medical emergency, and partial occlusion causes increased breathing rates and failure to wean off mechanical ventilation. Partial occlusion may be underestimated due to the lack of proper detection methods. We tested whether the sound of an endotracheal tube could be used to detect an endotracheal(More)
Nuclear magnetic resonance (NMR) studies on an HIV gp41 construct reported by Lakomek and colleagues in this issue of Structure have revealed the conformational dynamics of a possible trimeric prehairpin fusion intermediate and its interactions with lipids. Two alternative fusion pathways are compared based on this work and a previous NMR structure of a(More)
The steroidogenic acute regulatory (StAR) protein is generated in rodents from 1.6 kb and 3.5 kb mRNA formed by alternative polyadenylation. The zinc finger protein, TIS11B (also Znf36L1), is elevated by cAMP in adrenal cells in parallel with StAR mRNA. TIS11b selectively destabilizes the 3.5 kb mRNA through AU-rich sequences at the end of the 3'UTR. siRNA(More)
Perilla (Perilla frutescens) oil is very rich in α-linolenic acid, an omega-3 fatty acid. As it is widely reported that omega-3 fatty acid supplementation improves cognitive function in children and adults, feeding rats with perilla diets followed by analysis of proteomic changes in the hippocampus can provide valuable information on the mechanism of(More)
Although combined pulmonary fibrosis and emphysema (CPFE) might be relevant to lung cancer, no comparison studies have been done. We evaluated the risk of lung cancer among CPFE patients compared to IPF and emphysema patients. We retrospectively reviewed the medical records of patients who were diagnosed as CPFE, IPF and emphysema using chest CT scans at(More)