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Automated cell segmentation and tracking are critical for quantitative analysis of cell cycle behavior using time-lapse fluorescence microscopy. However, the complex, dynamic cell cycle behavior poses new challenges to the existing image segmentation and tracking methods. This paper presents a fully automated tracking method for quantitative cell cycle(More)
Rival penalized competitive learning (RPCL) has been shown to be a useful tool for clustering on a set of sample data in which the number of clusters is unknown. However, the RPCL algorithm was proposed heuristically and is still in lack of a mathematical theory to describe its convergence behavior. In order to solve the convergence problem, we investigate(More)
In this letter, we propose an efficient one-nearest-neighbor classifier of texture via the contrast of local energy histograms of all the wavelet subbands between an input texture patch and each sample texture patch in a given training set. In particular, the contrast is realized with a discrepancy measure which is just a sum of symmetrized Kullback-Leibler(More)
It is well known that the convergence rate of the expectation-maximization (EM) algorithm can be faster than those of convention Žrst-order iterative algorithms when the overlap in the given mixture is small. But this argument has not been mathematically proved yet. This article studies this problem asymptotically in the setting of gaussian mixtures under(More)
MOTIVATION Currently there are no curative anticancer drugs, and drug resistance is often acquired after drug treatment. One of the reasons is that cancers are complex diseases, regulated by multiple signaling pathways and cross talks among the pathways. It is expected that drug combinations can reduce drug resistance and improve patients' outcomes. In(More)
The Library of Integrated Network-based Cellular Signatures (LINCS) L1000 big data provide gene expression profiles induced by over 10 000 compounds, shRNAs, and kinase inhibitors using the L1000 platform. We developed csNMF, a systematic compound signature discovery pipeline covering from raw L1000 data processing to drug screening and mechanism(More)