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We propose a reconfigurable fault-tolerant deflection routing algorithm (FTDR) based on reinforcement learning for NoC. The algorithm reconfigures the routing table through a kind of reinforcement learning---Q-learning using 2-hop fault information. It is topology-agnostic and insensitive to the shape of the fault region. In order to reduce the routing(More)
Reliability has become a key issue of Networkson-Chip (NoC) as the CMOS technology scales down to the nanoscale domain. This paper proposes a Fault-on-Neighbor (FoN) aware deflection routing algorithm for NoC which makes routing decision based on the link status of neighbor switches within 2 hops to avoid fault links and switches. Simulation results(More)
A fully differential common-source cascode low noise amplifier(LNA) is presented for wireless receivers. The capacitive cross-coupling technique combined with cascode transistor is introduced to enhance LNA gain and reduce noise figure as well as the nonlinearity influence of cascaded transistors. A 2.6mm long on-chip folded dipole antenna is integrated(More)
Immune coagulation is a major contributor to the pathogenesis of xenograft rejection, viral-induced hepatocellular injury and cytokine-induced fetal loss syndrome. In this study, we investigated the contribution of the novel gene product, fibrinogen-like protein 2 (fgl2) prothrombinase, in mediating immune injury in experimental and human acute allograft(More)
The purpose of the present study was to develop a new nanoparticulate formulation for delivery of tacrolimus to reduce its kidney distribution and functional nephrotoxicity. Tacrolimus (TAC)-loaded bovine serum albumin (BSA) nanoparticles (TAC-BSA-NPs) were prepared by emulsification-dispersion technique. The obtained TAC-BSA-NPs, with 189.50±7.15 nm of(More)
Cyclic RGDyK (cRGDyK)-conjugated pH-sensitive polymeric micelles were fabricated for targeted delivery of paclitaxel to prostate cancer cells based on pH-sensitive copolymer poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) (PEOz-PLA) and cRGDyK-PEOz-PLA to enhance antitumor efficacy. The prepared micelles with an average diameter of about 28nm exhibited rapid(More)
The cytotoxicity of chemotherapeutic agents to healthy organs and drug resistance of tumor cells are believed to be the main obstacles to the successful cancer chemotherapy in the clinic. To ensure that anticancer drugs could be delivered to the tumor region, are quickly released from carriers in tumor cells and rapidly escape from endo/lysosomes,(More)
This paper proposes a low-overhead fault-tolerant deflection routing algorithm, which uses a layer routing table and two TSV state vectors to make efficient routing decision to avoid both TSV and horizontal link faults, for 3D NoC. The proposed switch is implemented in hardware with TSMC 65nm technology, which can achieve 250MHz. Compared with a(More)
The combination of a chemotherapeutic drug with a P-glycoprotein (P-gp) inhibitor has emerged as a promising strategy for treating multidrug resistance (MDR) cancer. To ensure that two drugs can be co-delivered to the tumor region and quickly released in tumor cells, tumor-targeted and pH-sensitive polymeric micelles were designed and prepared by combining(More)
Dual endosomal pH-sensitive micelles were designed and fabricated to deliver doxorubicin (DOX) for treating breast cancer based on a poly(2-ethyl-2-oxazoline) (PEOz)-DOX (PEOz-hyd-DOX) conjugate. PEOz-hyd-DOX was successfully synthesized by connecting DOX to PEOz via an acid cleavable hydrazone linker and self-assembled into nanosized micelles, which(More)