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Indole is an inter-species biofilm signal mediated by SdiA
It is shown here that indole is a non-toxic signal that controls E. coli biofilms by repressing motility, inducing the sensor of the quorum sensing signal autoinducer-1 (SdiA), and influencing acid resistance (e.g., hdeABD, gadABCEX). Expand
Differential Effects of Epinephrine, Norepinephrine, and Indole on Escherichia coli O157:H7 Chemotaxis, Colonization, and Gene Expression
Compared to indole, epinephrine and norepinephrine exert divergent effects on EHEC chemotaxis, motility, biofilm formation, gene expression, and colonization of HeLa cells. Expand
Indole as an intercellular signal in microbial communities.
The current knowledge and perspectives on indole signaling are discussed, and it appears indole plays an important role in bacterial physiology, ecological balance, and possibly human health. Expand
Temporal gene-expression in Escherichia coli K-12 biofilms.
Cold-shock protein transcriptional regulators (cspABFGI) appear to be positive biofilm regulators, and deletions in respiratory genes (e.g. gatZABCDR, agaBCY) were highly regulated in biofilms. Expand
YliH (BssR) and YceP (BssS) Regulate Escherichia coli K-12 Biofilm Formation by Influencing Cell Signaling
It is shown that deletion of yceP and yliH increases biofilm formation in continuous-flow chambers with minimal glucose medium by increasing biofilm mass, surface coverage, and mean thickness, and the genetic basis of the increase was related to differential expression of genes related to stress response for both mutants. Expand
Indole and 7‐hydroxyindole diminish Pseudomonas aeruginosa virulence
Corroborating these microarray results, indole and 7HI decreased production of pyocyanin, rhamnolipid, PQS and pyoverdine and enhanced antibiotic resistance, and indole affected the utilization of carbon, nitrogen and phosphorus, and 7 HI abolished swarming motility. Expand
Roles of indole as an interspecies and interkingdom signaling molecule.
Current knowledge regarding indole and its derivatives, their biotechnological applications and their role in prokaryotic and eukaryotic systems are presented. Expand
Apple Flavonoid Phloretin Inhibits Escherichia coli O157:H7 Biofilm Formation and Ameliorates Colon Inflammation in Rats
  • Jin-Hyung Lee, S. Regmi, +4 authors Jintae Lee
  • Medicine, Biology
  • Infection and Immunity
  • 19 September 2011
Results suggest that the antioxidant phloretin also acts as an inhibitor of E. coli O157:H7 biofilm formation as well as an anti-inflammatory agent in inflammatory bowel diseases without harming beneficial commensal E. Escherichia coli biofilms. Expand
Enterohemorrhagic Escherichia coli Biofilms Are Inhibited by 7-Hydroxyindole and Stimulated by Isatin
7-hydroxyindole is a potent EHEC biofilm inhibitor and is found to be nontoxic interspecies biofilm signals for enterohemorrhagic Escherichia coli O157:H7, E. coli K-12, and Pseudomonas aeruginosa. Expand
ZnO nanoparticles inhibit Pseudomonas aeruginosa biofilm formation and virulence factor production.
The results support that ZnO nanoparticles are potential antivirulence materials against recalcitrant P. aeruginosa infections and possibly other important pathogens. Expand