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Force-Regulated In Situ TCR–Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+ T Cells
We have recently shown that two-dimensional (2D) and force-regulated kinetics of TCR–peptide-bound MHC class I (pMHC-I) interactions predict responses of CD8+ T cells. To test whether these findingsExpand
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Accumulation of Serial Forces on TCR and CD8 Frequently Applied by Agonist Antigenic Peptides Embedded in MHC Molecules Triggers Calcium in T Cells
T cell activation by Ag is one of the key events in adaptive immunity. It is triggered by interactions of the TCR and coreceptor (CD8 or CD4) with antigenic peptides embedded in MHC (pMHC) moleculesExpand
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A TCR mechanotransduction signaling loop induces negative selection in the thymus
The T cell antigen receptor (TCR) expressed on thymocytes interacts with self-peptide major histocompatibility complex (pMHC) ligands to signal apoptosis or survival. Here, we found thatExpand
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Fluorescence Biomembrane Force Probe: Concurrent Quantitation of Receptor-ligand Kinetics and Binding-induced Intracellular Signaling on a Single Cell.
Membrane receptor-ligand interactions mediate many cellular functions. Binding kinetics and downstream signaling triggered by these molecular interactions are likely affected by the mechanicalExpand
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Contractile actomyosin arcs promote the activation of primary mouse T cells in a ligand-dependent manner
Mechano-transduction is an emerging but still poorly understood component of T cell activation. Here we investigated the ligand-dependent contribution made by contractile actomyosin arcs populatingExpand
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Development of an alternating tangential flow (ATF) perfusion‐based transient gene expression (TGE) bioprocess for universal influenza vaccine
An alternating tangential flow (ATF) perfusion‐based transient gene expression (TGE) bioprocess has been developed using human embryonic kidney (HEK) 293 cells to produce H1‐ss‐np, a promisingExpand
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This information is current as Molecules Triggers Calcium in T Cells Antigenic Peptides Embedded in MHC CD 8 Frequently Applied by Agonist Accumulation of Serial Forces on TCR and
T cell activation by Ag is one of the key events in adaptive immunity. It is triggered by interactions of the TCR and coreceptor (CD8 or CD4) with antigenic peptides embedded in MHC (pMHC) moleculesExpand