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MiR-21 Indicates Poor Prognosis in Tongue Squamous Cell Carcinomas as an Apoptosis Inhibitor
Purpose: We aim to examine miR-21 expression in tongue squamous cell carcinomas (TSCC) and correlate it with patient clinical status, and to investigate its contribution to TSCC cell growth,Expand
Long non-coding RNA NKILA inhibits migration and invasion of tongue squamous cell carcinoma cells via suppressing epithelial-mesenchymal transition
It is shown that NKILA is down-regulated in TSCC cancer tissues than that in matched adjacent noncancerous tissues and this function could act as a potential predictor for overall survival in patients with TSCC and a potential therapeutic target for TSCC intervention. Expand
Super-Enhancer-Associated Long Noncoding RNA HCCL5 Is Activated by ZEB1 and Promotes the Malignancy of Hepatocellular Carcinoma.
HCCL5 was transcriptionally driven by ZEB1 via a super-enhancer and was significantly and frequently overexpressed in human HCC tissues, correlating with worse overall survival of patients with HCC, and the data suggest that HCCL 5 may serve as a novel prognostic biomarker and therapeutic target in HCC. Expand
MiR-320a acts as a prognostic factor and Inhibits metastasis of salivary adenoid cystic carcinoma by targeting ITGB3
MiR-320a inhibits metastasis in SACCs by targeting ITGB3 and may serve as a therapeutic target and prognostic marker in salivary cancers. Expand
Downregulation of RGMA by HIF-1A/miR-210-3p axis promotes cell proliferation in oral squamous cell carcinoma.
Research indicates that RGMA is regulated by the HIF1A/miR-210-3p/RGMA axis and inhibits OSCC cell proliferation; thus, in the future, the development of therapies that target the Hif1A /miR -210- 3p/ RGMA axis may aid in the treatment of aggressive cancers. Expand
miR-639 regulates transforming growth factor beta-induced epithelial–mesenchymal transition in human tongue cancer cells by targeting FOXC1
Reduced expression of miR‐639 underscores the mechanism of TGFβ‐induced EMT in TSCC by targeting FOXC1 and may serve as therapeutic targets in the process of metastasis. Expand
Overexpression of EMMPRIN Isoform 2 Is Associated with Head and Neck Cancer Metastasis
The results of this study demonstrate the important role of EMMPRIN-2 in head and neck cancer progression for the first time and reveal that increased extracellular secretion of Cathepsin B may be a novel mechanism underlying EMMprin-2 enhanced tumor progression in head or neck cancer. Expand
Mitochondrial fission determines cisplatin sensitivity in tongue squamous cell carcinoma through the BRCA1–miR-593-5p–MFF axis
It is shown that MFF mediated mitochondrial fission and apoptosis in tongue squamous cell carcinoma (TSCC) cells after cisplatin treatment and that miR-593-5p was downregulated in this process, revealing a model for mitochondrial fissions regulation at the transcriptional and post-transcriptional levels. Expand
Upregulation of lncRNA ADAMTS9-AS2 Promotes Salivary Adenoid Cystic Carcinoma Metastasis via PI3K/Akt and MEK/Erk Signaling.
Overexpression of ADAMTS9-AS2 competitively bound to miR-143-3p that inhibited ITGA6 from miRNA-mediated degradation, and thus it activated the activity of PI3K/Akt and MEK/Erk signaling and facilitated SACC metastasis. Expand
Mitochondrial miRNA Determines Chemoresistance by Reprogramming Metabolism and Regulating Mitochondrial Transcription.
The mitomiR-2392 regulates chemoresistance in tongue squamous cell carcinoma (TSCC) cells by reprogramming metabolism via downregulation of oxidative phosphorylation and upregulation of glycolysis and uncovered a novel mechanism by which mitomiRNA regulates mitochondrial transcription. Expand