Jinrong Cheng

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CDC37 is a molecular chaperone that physically stabilizes the catalytic domains found in protein kinases and is therefore a wide-spectrum regulator of protein phosphorylation. It is also an overexpressed oncoprotein that mediates carcinogenesis by stabilizing the compromised structures of mutant and/or overexpressed oncogenic kinases. Recent work shows that(More)
Apo2L/TRAIL has considerable promise for cancer therapy based on the fact that this member of the tumor necrosis factor family induces apoptosis in the majority of malignant cells, while normal cells are more resistant. Furthermore, in many cells, when Apo2L/TRAIL is combined with chemotherapy, the effect is synergistic. The majority of this work has been(More)
The progression of prostate cancer to the castration-recurrent phenotype remains a major problem medically. The present study examined the transcriptomics of de novo androgen synthesis as a potential mechanism to escape from dependence on circulating androgen. VCaP, LNCaP and LAPC4 cells were acclimated to 1 nM testosterone for five generations before(More)
Crystalline solutions of 0.57(Bi(1-x)La(x))FeO(3)-0.43PbTiO(3) (BLF-PT) for x = 0, 0.1, 0.2, and 0.3 were fabricated by the traditional solid state reaction method. X-ray diffraction analysis revealed that the tetragonal torhombohedral phase transformation of BLF-PT occurred with an increase of the La content. The dielectric and ferroelectric properties of(More)
BiFeO<inf>3</inf>-PbTiO<inf>3</inf> (BFO-PT) thin films were fabricated by sol-gel technology. X-ray diffraction pattern reveals the BFO-PT films are in rhombohedral perovskite phase with random orientations. By Pt/BFO-PT/ITO/glass capacitor structure, co-measurement of electrical and optical responses can be achieved. Remanent polarization of(More)
Crystalline solutions of 0.65 Bi(0.94)La(0.06)) (Ga(x)Fe(1-x))O(3)-0.35PbTiO(3) Ceramics (BLGF-PT) for x = 0 and 0.05 have been fabricated by the solid-state reaction method. X-ray diffraction (XRD) was utilized to characterize the crystal structure and examine any possible impurities existing in the ceramics. The effects of Ga substitution on dielectric(More)
Fe-doped Ba(0.6)Sr(0.4)TiO3 (BST) thin films were prepared on Pt/Si substrates by the pulsed-laser deposition method. The concentrations of Fe dopants vary from 0.1 mol% to 1.0 mol%. Our results indicate that a certain amount of Fe dopants can decrease the dielectric loss of BST thin films without causing the significant reduction of the tunability. The(More)
Gadolinium doped BiFeO<inf>3</inf>-PbTiO<inf>3</inf> ((Bi<inf>1-x</inf>Gd<inf>x</inf>)FeO<inf>3</inf>-PbTiO<inf>3</inf>, BGF-PT) crystalline solution ceramics for x=0, 0.1, 0.2 and 0.3 are studied in this report. X-ray diffraction (XRD) result reveals that all ceramics are in single perovskite structure. Phase transition from rhombohedral to tetragonal is(More)
(1-x)(Bi(0.9)La(0.1))FeO(3-x)PbTiO(3) (BLF-PT) crystalline solutions for x = 0.35, 0.37, 0.4, 0.43 and 0.45 have been prepared by the solid-state reaction method. The X-ray diffraction analysis shows that BLF-PT has a single perovskite phase with mixed tetragonal and rhombohedral phases between x = 0.4 and 0.43. The Curie temperature of BLF-PT for x = 0.4(More)
Bismuth ferrite and lead titanate composite multiferroic films (xBiFeO<inf>3</inf>-(1-x)PbTiO<inf>3</inf>, BFO-PT films) were deposited on Pt/Ti/SiO<inf>2</inf>/Si substrates by sol-gel method. In this report, the value of x varies from 0.5 to 0.8. The composition dependence (dependence of x) of BFO-PT films is studied. X-ray diffraction analysis reveals(More)