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MicroRNA-26a promotes cholangiocarcinoma growth by activating β-catenin.
BACKGROUND & AIMS MicroRNAs (miRNAs) have been implicated in the development and progression of human cancers. We investigated the roles and mechanisms of miR-26a in human cholangiocarcinoma. Expand
Active glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122
It is suggested that enhanced glycolysis is associated with CD133 (+) stem-like characteristics and that metabolic reprogramming through miR-122 or PDK4 may represent a novel therapeutic approach for the treatment of hepatocellular cancer. Expand
Resveratrol reduces acute lung injury in a LPS‑induced sepsis mouse model via activation of Sirt1.
It is demonstrated that resveratrol inhibits LPS‐induced ALI and inflammation via Sirt1, and indicated that Sirt 1 is an efficient target for the regulation of LPS‑induced ALi and inflammation. Expand
SIRT3 regulates cell proliferation and apoptosis related to energy metabolism in non-small cell lung cancer cells through deacetylation of NMNAT2
The results strongly suggest that the binding of SIRT3 with NMNAT2 is a novel regulator of cell proliferation and apoptosis in NSCLC cell lines, implicating the interaction between Sirt3 and NM NAT2, energy metabolism associated with SIRT2. Expand
SSRP1 Contributes to the Malignancy of Hepatocellular Carcinoma and Is Negatively Regulated by miR-497
It is proved that SSRP1 upregulation contributed to HCC development and the tumor-suppressive miR-497 served as its negative regulator. Expand
SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling.
It is demonstrated that overexpression of SIRT1 promotes tumorigenesis of hepatocellular carcinoma (HCC) through the PTEN/PI3K/AKT signaling pathway and may serve as a novel target for selective killing of cancer versus normal liver cells. Expand
miR-150 Deficiency Protects against FAS-Induced Acute Liver Injury in Mice through Regulation of AKT
It is demonstrated that miR-150 deficiency prevents Fas-induced hepatocyte apoptosis and liver injury through regulation of the Akt pathway. Expand
The Histone Methyltransferase G9a Promotes Cholangiocarcinogenesis Through Regulation of the Hippo Pathway Kinase LATS2 and YAP Signaling Pathway
Evidence is presented that the histone‐lysine methyltransferase G9a is up‐regulated in human CCA and that G 9a enhances CCA cell growth and invasiveness through regulation of the Hippo pathway kinase large tumor suppressor 2 (LATS2) and yes‐associated protein (YAP) signaling pathway. Expand
Epigenetic regulation of MicroRNA‐122 by peroxisome proliferator activated receptor‐gamma and hepatitis b virus X protein in hepatocellular carcinoma cells
It is shown that hepatitis B virus X protein binds PPARγ and inhibits the transcription of miR‐122, whereas hepatitis C viral particles exhibited no significant effect; these findings provide mechanistic insight into reduction of mi R‐122 in patients with HBV but not with HCV infection. Expand
miR-185 inhibits hepatocellular carcinoma growth by targeting the DNMT1/PTEN/Akt pathway.
Novel evidence is provided that miR-185 inhibits HCC cell growth by targeting DNMT1, leading to PTEN induction and Akt inhibition, which provides novel evidence that reactivation or induction of mi R-185 may represent a novel therapeutic strategy for HCC treatment. Expand