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Approximately half of the world's 500,000 new oesophageal squamous-cell carcinoma (ESCC) cases each year occur in China. Here, we show whole-genome sequencing of DNA and RNA in 94 Chinese individuals with ESCC. We identify six mutational signatures (E1-E6), and Signature E4 is unique in ESCC linked to alcohol intake and genetic variants in(More)
The objective of our research was to reveal the effects of shear stress on the apoptosis of cultured human umbilical vein endothelial cells (HUVECs) induced by lipopolysaccharide (LPS). A parallel-plate flow chamber was used to control the strength and duration of shear stress (SS), and apoptosis was measured by immunocytochemistry and radio-immunoassay.(More)
In this study we investigated the patterns of fluid shear stress on induction of monocyte chemoattractant protein-1 (MCP-1) secretion in cultured human umbilical vein endothelial cells (HUVECs). MCP-1 is a potent special chemoattractant, which recruits monocytes into the sub-endothelium. This process is one of the early events of atherosclerosis. We(More)
The survival rate associated with esophageal cancer is very poor due to diagnosis at advanced stages of disease and insensitivity to chemotherapy. This study investigated the efficacy of gefitinib combination with radiation in 20 elderly patients with esophageal squamous cell carcinoma (ESCC) who were not eligible for platinum-based chemotherapy.(More)
OBJECTIVE To investigate the mechanism of activation of platelet by shear stress. METHODS Specimens of whole blood were exposed to shear stress of different intensity (100, 150, 1,000, and 3,000 s(-1)) by modified cone-and-plate rotational viscometer. Then the platelets were stained with fluorescent antibody technique by flow cytometry to examine the(More)
INTRODUCTION In the Western world, malignant mesothelioma (MM) is most prevalent in the pleura of older males who have been professionally exposed to asbestos. Information about MM from rapidly industrializing countries such as China is minimal. There is concern that a proportion of MM diagnoses in China may be incorrect because most Chinese physicians do(More)
The objective of our research was to reveal the effects of different shear stresses on the expression of proto-oncogenes c-fos and c-myc in cultured human umbilical vein endothelial cells (HUVEC). A parallel plate flow chamber was used to control the value and duration of shear stress (SS), and the expression of c-fos and c-myc protein was measured by(More)
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