Jinlei Guo

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The accumulation of single-stranded DNA-binding (SSB) proteins is essential for organisms and has various applications. However, no study has simultaneously and systematically compared the characteristics of SSB proteins. In addition, SSB proteins may bind RNA and play an unknown biological role in RNA metabolism. Here, we expressed a novel species of SSB(More)
Mannose-binding lectin (MBL), a pattern-recognition molecule in serum, recognizes specific hexose sugars rich in mannose and N-acetylglucosamine on bacterium, yeasts, viruses as well as apoptotic cells. It has been well-identified that MBL has antiviral effects via binding to seasonal influenza H1 and H3 subtype viruses. Influenza A (H7N9) virus, a novel(More)
Hemagglutinin (HA) contains a head domain with a high degree of variability and a relatively conserved stem region. HA is the major viral antigen on the surface of the influenza virus. To define the biologic activities of chimeric HA bearing different head domains and stem regions or their potential use, a HA chimeric gene containing the head domain of the(More)
Influenza is a contagious, acute respiratory disease caused by influenza viruses. Type A influenza virus has a broad host range and has caused substantial human morbidity and mortality. There are sixteen subtypes of influenza A virus so far, which are divided into two distinct groups: group 1 (H1, H2, H5, H6, H8, H9, H11, H12, H13 and H16) and group 2 (H3,(More)
Amino acid substitutions (H3 numbering) 47 57 59 82 84 114 128 135 150 173 177 215 266 274 276 284 312 326 A/Anhui/1/2013 N R T F A E S A E K L P M V N S R I A/Jiangsu/05/2013 . . . . . . . A/S . . . . . . . . . . A/environment/Jiangsu/03137/2013 . . . . . . . . . . I . . . . . . . A/environment/Guangdong/25003/2013 . . . . . . . . D . I . . . . . . .(More)
The aim of this study was to characterize HIV-1 genotypes and antiretroviral resistance mutations among treatment-naive HIV-infected individuals in Jiaxing, China. The HIV-1 partial polymerase (pol) genes in 93 of the 99 plasma samples were successfully amplified and analyzed. Phylogenetic analysis revealed the existence of five HIV-1 genotypes, of which(More)
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