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Here we present an active patterning technique named "acoustic tweezers" that utilizes standing surface acoustic wave (SSAW) to manipulate and pattern cells and microparticles. This technique is capable of patterning cells and microparticles regardless of shape, size, charge or polarity. Its power intensity, approximately 5x10(5) times lower than that of(More)
This work introduces a method of continuous particle separation through standing surface acoustic wave (SSAW)-induced acoustophoresis in a microfluidic channel. Using this SSAW-based method, particles in a continuous laminar flow can be separated based on their volume, density and compressibility. In this work, a mixture of particles of equal density but(More)
We present ultra-fast homogeneous mixing inside a microfluidic channel via single-bubble-based acoustic streaming. The device operates by trapping an air bubble within a "horse-shoe" structure located between two laminar flows inside a microchannel. Acoustic waves excite the trapped air bubble at its resonance frequency, resulting in acoustic streaming,(More)
  • Xiaoyun Ding, Sz-Chin Steven Lin, +6 authors Tony Jun Huang
  • Proceedings of the National Academy of Sciences…
  • 2012
Techniques that can dexterously manipulate single particles, cells, and organisms are invaluable for many applications in biology, chemistry, engineering, and physics. Here, we demonstrate standing surface acoustic wave based "acoustic tweezers" that can trap and manipulate single microparticles, cells, and entire organisms (i.e., Caenorhabditis elegans) in(More)
The recent introduction of surface acoustic wave (SAW) technology onto lab-on-a-chip platforms has opened a new frontier in microfluidics. The advantages provided by such SAW microfluidics are numerous: simple fabrication, high biocompatibility, fast fluid actuation, versatility, compact and inexpensive devices and accessories, contact-free particle(More)
Three-dimensional (3D) continuous microparticle focusing has been achieved in a single-layer polydimethylsiloxane (PDMS) microfluidic channel using a standing surface acoustic wave (SSAW). The SSAW was generated by the interference of two identical surface acoustic waves (SAWs) created by two parallel interdigital transducers (IDTs) on a piezoelectric(More)
We have developed an acoustic-based tunable patterning technique by which microparticles or cells can be arranged into reconfigurable patterns in microfluidic channels. In our approach, we use pairs of slanted-finger interdigital transducers (SFITs) to generate a tunable standing surface acoustic wave field, which in turn patterns microparticles or cells in(More)
We report a tunable optofluidic microlens configuration named the Liquid Gradient Refractive Index (L-GRIN) lens for focusing light within a microfluidic device. The focusing of light was achieved through the gradient refractive index (GRIN) within the liquid medium, rather than via curved refractive lens surfaces. The diffusion of solute (CaCl(2)) between(More)
displays, [ 3 ] microlenses, [ 4 , 5 ] lasers, [ 6 , 7 ] and data storage, [ 8 ] due to their excellent electro-optical properties. PDLC fi lms can be prepared between two conductive, transparent substrates using methods such as encapsulation, thermally induced phase separation, solvent-induced phase separation, and polymerizationinduced phase separation. [(More)